Lipid Signaling in Human Diseases /
Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their react...
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Published: |
Cham :
Springer International Publishing : Imprint: Springer,
2020.
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| Edition: | 1st ed. 2020. |
| Series: | Handbook of Experimental Pharmacology,
259 |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Part 1. New Roles for Sphingolipid Signaling and Cell Function
- 1. Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma
- 2. Exploring the Therapeutic Landscape of Sphingomyelinases
- 3. Sphingosine kinases as druggable targets
- Part 2. Phospholipase D and Mitogen Phosphatidic Acid in Human Disease
- 4. Prospects for PLD inhibition in cancer and thrombotic disease
- 5. Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer
- 6. Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease
- Part 3. Lipid Kinases and Novel Regulatory Pathways
- 7. Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors
- 8. Functions of Nuclear Polyphosphoinositides
- Part 4. Bioactive Lipids in Health and Disease
- 9. Platelet-Activating Factor as an Effector for Environmental Stressors
- 10. Phospholipase D and Choline Metabolism
- Part 5- Lipids and Membrane Microdomains
- 11. Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology
- 12. Lipids and Membrane Microdomains: The Glycerolipid and Alkylphosphocholine Class of Cancer Chemotherapeutic Drugs
- Part 6. Nuclear Trafficking of Lipids
- 13. Inositide-Dependent Nuclear Signalling in Health and Disease
- 14. Lipids in Exosome Biology.