Biophysics and biochemistry of cartilage by NMR and MRI /
This unique book describes the latest information in the fundamental understanding of the biophysics and biochemistry of articular cartilage using the state-of-the-art practices in NMR and MRI.
| Other Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
Cambridge :
Royal Society of Chemistry,
2017.
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| Series: | New developments in NMR ;
no. 8. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Cover; Biophysics and Biochemistry of Cartilage by NMR and MRI; Preface; Acknowledgements; Contents; Part One
- Introduction; Chapter 1
- Introduction to Cartilage; 1.1 Introduction; 1.2 Cartilage and the Joint; 1.2.1 Different Types of Cartilage; 1.2.2 Synovial Joints and Articular Cartilage; 1.3 Cellular Aspects of Articular Cartilage; 1.3.1 Cartilage Progenitor Cells; 1.3.2 Mature Chondrocytes in Cartilage; 1.3.3 Mesenchymal Stem Cells; 1.4 Extracellular Matrix of Articular Cartilage; 1.4.1 Collagen; 1.4.2 Proteoglycans and Glycosaminoglycans; 1.4.3 Water; 1.4.4 Other Components.
- 1.5 Histological Structure of Articular Cartilage1.5.1 The Zonal Structure of Articular Cartilage; 1.5.2 Depth-Dependent Physicochemical Properties; 1.6 Biomechanical Properties of Articular Cartilage; 1.6.1 The Uncompressed Equilibrium State; 1.6.2 Compression of Articular Cartilage; 1.7 Joint and Gross Morphology of Articular Cartilage; 1.7.1 Development of Synovial Joint; 1.7.2 Topographic Distributions in the Knee; 1.7.3 Topographic Distributions in the Shoulder; 1.7.4 The Split-Line Pattern; 1.8 The Diseases of Cartilage and Joints; 1.8.1 Classification and Etiology of Osteoarthritis.
- 1.8.2 Pathogenesis1.8.3 The Role of Subchondral Bone; 1.8.4 Biomarkers; 1.8.5 Treatment; 1.9 Osteoarthritis Research; 1.9.1 In vivo Models of Osteoarthritis; 1.9.2 In vitro Models of Cartilage Degeneration; Acknowledgements; References; Chapter 2
- Osmotic Properties of Cartilage; 2.1 Introduction; 2.2 Cartilage Molecular Architecture, Gross Appearance, and Morphology; 2.3 Osmotic Swelling Pressure of Cartilage; 2.4 Molecular Interactions of Cartilage Polymers; 2.4.1 Osmotic Observations; 2.4.2 Small-Angle Scattering Measurements; 2.4.3 Dynamic Properties of Proteoglycan Assemblies.
- 2.5 ConclusionsAcknowledgements; References; Chapter 3
- Introduction to NMR and MRI; 3.1 Introduction; 3.2 Semiclassical Description of NMR; 3.2.1 NMR-Active Nuclei; 3.2.2 Vector Description of NMR; 3.2.3 Excitation; 3.2.4 Precession and the Bloch Equation; 3.2.5 Rotating Frame; 3.2.6 Chemical Shielding and Chemical Shift; 3.2.7 Spin Relaxation; 3.2.8 NMR Signal Detection; 3.2.9 Spin Echo and NMR Pulse Sequences; 3.3 Quantum Description of NMR; 3.3.1 Spin and Angular Momentum; 3.3.2 Conceptual Points; 3.3.3 Matrix Representation of Spin Operators; 3.3.4 Zeeman Hamiltonian.
- 3.3.5 Nuclear Magnetisation3.3.6 Evolution of the Spin Density Matrix; 3.3.7 NMR Observables and Coherence Order; 3.3.8 Spin Relaxation; 3.3.9 Anisotropic Spin Hamiltonians and NMR Spectra; 3.4 MRI; 3.4.1 Fourier MRI; 3.4.2 Implementation of Fourier Imaging; 3.4.3 Image Contrast; 3.4.4 Spatial Resolution and the SNR; 3.4.5 Parameter Mapping Versus Weighted Imaging; 3.5 Conclusion; Abbreviations and Symbols; Acknowledgements; References; Chapter 4
- The Magic Angle Effect in NMR and MRI of Cartilage; 4.1 Introduction; 4.2 Basic Physics and Physical Chemistry.