High throughput screening methods : evolution and refinement /

Bibliographic Details
Other Authors:	Bittker, Joshua A. (Editor), Ross, Nathan T. (Editor)
Format:	eBook
Language:	English
Published:	[Cambridge, England] : Royal Society of Chemistry, 2016.
Subjects:	High throughput screening (Drug development) Biology, life sciences. SCIENCE > Chemistry > Industrial & Technical. SCIENCE > Life Sciences > Biology. Scientific equipment, experiments & techniques. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Perspective/overview: State of the art in HTS at the academic-industry interface; Assay design and optimization; Assessment of available compound collections; Novel approaches to discovery and analysis of interesting compound combinations; Modern biophysical methods in target-based screening; Genetic perturbation methods; Understanding luminescence-based screens; Measuring interactions in live cells; Approaches to high-content imaging and multi-feature analysis; Profiling of genetically characterized cell systems; Multidimensional profile-based screening; Using biological systems that better recapitulate physiology; Phenotypic screens with model organisms; Encoded libraries; Modern virtual screening; Research data management; Small molecule bioactivity databases; Chemical biology in a pharma environment; Practical aspects of funding and executing high-throughput screens