rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Epigenetics for drug discovery
  name:
    name part: Carey, Nessa
    role:
      role term: editor.
  name:
    name part: Royal Society of Chemistry (Great Britain)
    role:
      role term: issuing body.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: enk
    date issued: 2015
    copyright date: 2016
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xv, 321 pages)
  abstract: Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington₂s disease and from inflammation to sickle cell anaemia. The book is structured in three main sections. The first section introduces epigenetics and explain its importance at both a phenomenological and molecular level. The second section goes on to review how each of the big breakthroughs in drug discovery in this field have developed, with a strong emphasis on case histories. The final section highlights the ongoing challenges in creating safe and efficacious epigenetic drugs. Written and edited by experts within the field from both industry and academia, this book provides an invaluable guide to this developing field for medicinal chemists working in academia and in the pharmaceutical industry.
  table of contents: Epigenetics -- What it is and Why it Matters; Enzyme and Protein Families that Regulate Histone Modifications and Crosstalk; Epigenetics and Disease; Targeting DNA Methylation; Targeting Histone Acetylation; Targeting Histone Lysine Methyltransferases in Cancer; Targeting Non-Acetylation Histone Erasers; Progress in Targeting Epigenetic Readers; Who will Bebefit from Epigenetic Drugs; Dosing -- When Less Is More; Histone Methyltransferase Activity Assays; Safety Considerations for Epigenetic Mechanisms as Drug Targets: Are Existing Toxicology Studies Fit for Purpose?
  note: edited by Nessa Carey.
  note: Includes bibliographical references and index.
  subject:
    topic: Drug targeting
  subject:
    topic: Epigenetics
  subject:
    topic: Pharmacogenetics
  subject:
    topic: Drug Delivery Systems
  subject:
    topic: Epigenesis, Genetic
  subject:
    topic: Pharmacogenetics
  subject:
    topic: Cellular biology (cytology)
  subject:
    topic: Drug development
  subject:
    topic: Drug targeting
  subject:
    topic: Epigenetics
  subject:
    topic: Pharmacogenetics
  subject:
    topic: Pharmacology
  subject:
    topic: SCIENCE
    topic: Life Sciences
    topic: Biochemistry
  subject:
    topic: SCIENCE
    topic: Life Sciences
    topic: Biology
  classification: RM301.3.G45
  classification: 615.7
  classification: QV 38.5
  related item:
    title info:
      title: Epigenetics for drug discovery
    identifier: (OCoLC)931624475
  related item:
    title info:
      title: RSC drug discovery series ; 48
  identifier: 1782627723
  identifier: 1782628487
  identifier: 9781782627722
  identifier: 9781782628484
  identifier: 1849738823
  identifier: 9781849738828
  identifier: 3610:3492 Royal Society of Chemistry
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: UKRSC
    record creation date: 151214
    record change date: 20210305090154.0
    record identifier: in00004358300
    language of cataloging:
      language term: eng