rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Privileged scaffolds in medicinal chemistry
    sub title: design, synthesis, evaluation
  name:
    name part: Bräse, Stefan
    role:
      role term: editor.
  name:
    name part: Royal Society of Chemistry (Great Britain)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: enk
    date issued: 2015
    copyright date: 2016
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (570 pages)
  abstract: One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments. The first of the benzodiazepines, a class of drugs that is powerful for treating anxiety, may not have been discovered had it not been for a chance experiment on the contents of a discarded flask found during a lab clean-up. Some years later, scientists discovered that benzodiazepine derivatives were also effective in treating other diseases. This class of molecules was the first to be described as privileged in the sense that it is especially effective at altering the course of disease. Other privileged molecular structures have since been discovered, and since these compounds are so effective at interacting with numerous classes of proteins, they may be an effective starting point to look for new drugs against the supposedly ₃undruggable₄ proteins. Following introductory chapters presenting an overview, a historical perspective and the theoretical background and findings, main chapters describe the structure of privileged structures in turn and discuss major drug classes associated with them and their syntheses. This book provides comprehensive coverage of the subject through chapters contributed by expert authors from both academia and industry and will be an excellent reference source for medicinal chemists of a range of disciplines and experiences.
  table of contents: Cover; Preface; Contents; Chapter 1 Privileged Scaffolds in Medicinal Chemistry: An Introduction; 1.1 Introduction; 1.2 The Privileged Scaffolds in Drug Discovery; 1.3 Conclusion; Acknowledgments; References; Chapter 2 Privileged Scaffolds in Medicinal Chemistry -- A Computational Approach; 2.1 Introduction; 2.2 Scope of the Study; 2.3 Privileged Scaffolds; 2.4 Molecular Docking; 2.5 Protein Structure Prediction; 2.5.1 Comparative Modeling; 2.5.2 Threading (Fold Recognition); 2.5.3 Model Building and Refinement; 2.5.4 Loop Modeling; 2.5.5 Side Chain Modeling; 2.5.6 Model Building
  table of contents: 4.1.4 Natural Products Containing (Benz)imidazoles4.2 Case Studies of Marketed Drugs; 4.2.1 Angiotensin II Receptor Antagonists; 4.2.2 H+, K+-ATPase Inhibitors; 4.2.3 H1-antihistamines; 4.2.4 Anthelmintics; 4.2.5 Miscellaneous; References; Chapter 5 Pyrazoles; 5.1 General Remarks about Pyrazoles; 5.1.1 Physicochemical Properties of Pyrazoles; 5.1.2 Synthesis of Pyrazoles; 5.1.3 Natural Products Containing Pyrazoles; 5.2 (Former) Marketed Drugs; 5.2.1 Anti-inflammatory Drugs; 5.2.2 Vasodilators; 5.2.3 Tyrosine-kinase-inhibitors; 5.2.4 Cannabinoid-receptor-antagonists
  note: editor: Stefan Bräse.
  note: Includes index.
  note: Title from title details screen (Royal Society of Chemistry, viewed December 14, 2015).
  subject:
    topic: Pharmaceutical chemistry
  subject:
    topic: Scaffold proteins
  subject:
    topic: Biochemistry
  subject:
    topic: Chemistry
  subject:
    topic: Pharmaceutical chemistry
  subject:
    topic: SCIENCE / Life Sciences / Biochemistry
  subject:
    topic: Scaffold proteins
  classification: RS403
  classification: 615.1/9
  related item:
    title info:
      title: Privileged Scaffolds in Medicinal Chemistry : Design, Synthesis, Evaluation
    name:
      name part: Jakubczyk, Dorota.
    origin info:
      publisher: Cambridge : Royal Society of Chemistry, ©2015
  related item:
    title info:
      title: RSC drug discovery series
  identifier: 1782622241
  identifier: 1782627790
  identifier: 9781782622246
  identifier: 9781782627791
  identifier: 1782620303
  identifier: 9781782620303
  identifier: 3869:3747 Royal Society of Chemistry
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: UKRSC
    record creation date: 151214
    record change date: 20210308110850.0
    record identifier: in00004358299
    language of cataloging:
      language term: eng