Reducing, refining and replacing the use of animals in toxicity testing /

Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed wh...

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Bibliographic Details
Other Authors:	Allen, David G. (David Glenwood) (Editor), Waters, Mike D. (Editor)
Format:	eBook
Language:	English
Language Notes:	English.
Published:	Cambridge : Royal Society of Chemistry, [2013]
Series:	Issues in toxicology.
Subjects:	Alternative toxicity testing. Toxicity testing. Animal Experimentation. Animal Population Groups. Animal Testing Alternatives. Animal Use Alternatives. Animals, Laboratory. Animals. Eukaryota. Investigative Techniques. Organisms. Toxicity Tests. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Introduction;The 3R's in Toxicity Testing
From Russell and Birch to 21st Century Toxicology; Regulatory Safety Testing
National and International Requirements; Efforts Towards International Harmonization of Acceptable Alternatives; Refinement Alternatives
Minimizing Pain and Distress in In Vivo Toxicity Testing; In Vitro Toxicity Testing
The Basics; Using Stem Cells in Toxicity Testing; Using Computers Instead of Cells
In Silico Approaches to Toxicity Testing; Acute Safety Testing; Acute Systemic Toxicity
Oral, Dermal, and Inhalation Exposures;Dermal Corrosivity and Irritation Testing; Ocular Corrosivity and Irritation Testing; Skin Sensitization Testing; Integrated Approaches to Acute Safety Testing; Endocrine Disruptors; In Vitro Receptor Binding Assays; In Vitro Receptor Transactivation Assays; Non-mamalian Approaches to Identifying Endocrine Active Substances; Subchronic and Chronic Toxicity Testing; Carcinogenicity
Genetic Toxicity Testing and Beyond; Reproductive and Developmental Toxicity Testing; Immunotoxicity Testing; Application of New Technologies; High Throughput Approaches to Toxicity Testing; Nanotechnology
New Challenges in Toxicity Testing