Proteinases as drug targets /
This book provides vital information on a class of enzymes that have emerged as key drug targets in a number of human diseases, including HIV/AIDS, Hypertension, Cancer, and Alzheimer's disease. There is a gap in information due to the lack of recent international meetings on this subject and,...
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| Format: | eBook |
| Language: | English |
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Cambridge, U.K. :
Royal Society of Chemistry,
[2011]
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| Series: | RSC drug discovery series.
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| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Dipeptidyl peptidases: Substrates and therapeutic targeting in human health and disease; The Metalloproteases Meprin? and?: Pathophysiological roles in Inflammation, Cardiovascular Disease, Cancer, and Fibrosis; Glutamate Carboxypeptidase II as a Therapeutic Target; The Role of Proteolytically Inactive Serine Proteases from Sarcoptes scabiei in Complement Evasion; Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy; Discovery of the Cysteine Protease Cathepsin B as a Drug Target for Alzheimer's Disease; Plasmodium falciparum Neutral Aminopeptidases: Development of novel anti-malarials by understanding enzyme structure; Blood-feeding human hookworm proteases; Structural Mechanisms of Inactivation in Proteolytically Inactive Serine Proteases from Sarcoptes scabiei; The Aspartic Proteinases from the Malaria Parasite: Structure and Function of the Plasmepsins