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Metabolism, pharmacokinetics and toxicity of functional groups : impact of the building blocks of medicinal chemistry in ADMET /

Until now, the area of drug metabolism and pharmacokinetics has been lacking in texts written for the Medicinal Chemist. This outstanding book, aimed at postgraduate medicinal chemists and those working in industry, fills this gap in the literature. Written by medicinal chemists and ADMET scientists...

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Bibliographic Details
Other Authors: Smith, Dennis A.
Format: eBook
Language:English
Published: Cambridge : Royal Society of Chemistry, 2010.
Series:RSC drug discovery series.
Subjects:
Pharmacokinetics.
Chemistry, Pharmaceutical > methods.
Pharmaceutical Preparations > metabolism.
Drugs > Metabolism.
Functional groups.
Toxicity testing.
MEDICAL > Pharmacology.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Drug targets and their structural motifs
  • ADMET for the medicinal chemist
  • Carboxlic acids and their isosteres
  • Primary, secondary and tertiary amines and isosteres
  • Sulphonamide as an essential group
  • 1, 2 and 3 ring phenyl and heterocyclic cores
  • Heterocycles and phenyls as essential pharmacophore groups
  • Peptides and peptidomimetic cores
  • Peptides and peptidomimetics as functional groups
  • Transition state functions
  • Alcohols and carbonyls
  • Future targets and chemistry needs.