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Hormone-disruptive chemical contaminants in food
Today, we are surrounded by a multitude of different chemicals that are essential components of our everyday life. As a consequence, there are various hazardous substances like dioxins, phthalates and flame-retardants circulating in the environment. These have an impact on ecosystems, wildlife and possibly human health. In recent years, the phenomenon called endocrine disruption has raised considerable concern. This book discusses the scientific basis of this issue using epidemiological and experimental in vitro and in vivo data about chemicals targeting the hormonal systems. It also provides an up-to-date review of international initiatives (including high-throughput screening, use of model organisms and in silico applications) aiming to screen, detect and functionally test these chemicals.
Introduction; Human exposure to food-borne chemicals; Persistent organic pollutants (POPs) in food; Chemicals targeting the reproductive axis; Hormone-disruptive chemicals: effects on coming generations through epigenetic mechanisms; Naturally occurring, hormonally active compounds in our diet; ER isoforms as targets for nutrients and xenoestrogens; From exposure to effects: Role of metabolism in the bioactivation/detoxication of food contaminants; Aryl hydrocarbon receptor (AhR) and bHLH-PAS transcription factors targeted by dietary and xenobiotic compounds; Small model organisms as tools in food safety research; Reporter animals as tools in food safety research; In silico screening approaches; Genomic approaches to toxicology and nutrition; Large-scale screening of chemicals; Summary and future perspectives.
Ingemar Pongratz, Linda Bergander, editors.