New horizons in predictive toxicology : current status and application /

The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industri...

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Bibliographic Details
Corporate Author:	Royal Society of Chemistry (Great Britain)
Other Authors:	Wilson, A. G. E., 1947-
Format:	eBook
Language:	English
Published:	Cambridge, U.K. : Royal Society of Chemistry, 2011.
Series:	RSC drug discovery series ; 12.
Subjects:	Toxicology > methods. Forecasting > methods. Risk Assessment > methods. Biological Science Disciplines. Delivery of Health Care. Environment and Public Health. Epidemiologic Measurements. Epidemiologic Methods. Forecasting. Health Care Evaluation Mechanisms. Health Care Quality, Access, and Evaluation. Health Occupations. Health Services Administration. Investigative Techniques. Models, Theoretical. Natural Science Disciplines. Organization and Administration. Pharmacology. Probability. Public Health. Quality of Health Care. Risk Assessment. Risk Management. Risk. Social Sciences. Statistics as Topic. Toxicology. Toxicology > Animal models. Toxicology > Simulation methods. Chemistry. MEDICAL > Toxicology. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Acknowledgements
Chapter 1. Introduction and overview / Alan G.E. Wilson
Chapter 2. In silico tools for toxicity prediction / Mark T.D. Cronin
Chapter 3. Development of an evaluation support system for estimating repeated-dose toxicity of chemicals based on chemical structure / Makoto Hayashi and Yuki Sakuratani
Chapter 4. Towards a common regulatory framework for computational toxicology: current status and future perspectives / Andrew P. Worth and Aleksandra Mostrag-Szlichtyng
Chapter 5. Information, informatics and modeling in predictive toxicology / Scott Boyer, Daniel Muthas and Nigel Greene
Chapter 6. Cellular stress and in vitro predictive toxicology / Xuemei Liu, Jeffrey A. Kramer and Alan G.E. Wilson
Chapter 7. In vitro genotoxicity / John J. Nicolette [and others]
Chapter 8. Cardiac toxicity prediction: to simplify, or to integrate, that is the question / Vivek J. Kadambi, Colleen Synan and Katherine Brewer
Chapter 9. In vitro approaches for determining liver-specific toxicity of new drug candidates / James M. McKim Jr.
Chapter 10. Human-based in vitro experimental systems for the assessment of human-specific adverse drug effects: scientific concepts, current applications and promising approaches / Albert P. Li
Chapter 11. Pathways of organ injury to define human response in organotypic cultures / Alison E.M. Vickers
Chapter 12. Predicting drug-induced mitochondrial dysfunction / Sashi Nadanaciva and Yvonne Will
Chapter 13. Non-clinical models for the evaluation of mechanisms of toxicity / Jeffrey A. Kramer
Chapter 14. In vivo approaches to predictive toxicology using zebrafish / Michael T. Simonich, Jill A. Franzosa and Robert L. Tanguay
Chapter 15. In vivo genetic toxicology: application to cancer risk assessment / Michael J. Schlosser and Christopher S. Farabaugh
Chapter 16. Predicting hepatotoxicity in vivo / Timothy Maziasz
Chapter 17. Immunotoxicity testing / Thomas T. Kawabata [and others]
Chapter 18. In vitro developmental models and their applications in teratology research / Karen Augustine-Rauch, Julieta M. Panzica-Kelly and Cindy X. Zhang
Chapter 19. Role and status of bridging biomarkers in predictive toxicology / William B. Mattes
Chapter 20. Renal toxicity / K. Nasir M. Khan, Gordon C. Hard and Zaher A. Radi
Chapter 21. Metabolism-based toxicology prediction / F. Peter Guengerich
Chapter 22. Impact of drug transporters in the pharmacological and adverse reactions of drugs / Hiroyuki Kusuhara, Kazuya Maeda and Yuichi Sugiyama
Chapter 23. Toxicokinetics / Dennis A. Smith
Chapter 24. The role of computational systems biology models in toxicity testing in the 21st century: an example with predictive multi-scale models of the liver / Sudin Bhattacharya [and others]
Chapter 25. Animal models of idiosyncratic, drug-induced liver injury / Christine M. Dugan, Patricia E. Ganey and Robert A. Roth
Subject index.