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Therapeutic oligonucleotides /

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This book provides a comprehensive overview of the development of therapeutic oligonucleotides for therapeutic applications, touching on a number of additional oligonucleotides including a number of small interfering RNAs currently in various phases of clinical development. Written by leading expert...

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Bibliographic Details
Other Authors: Kurreck, Jens, 1969-
Format: eBook
Language:English
Published: Cambridge : RSC Pub., [2008]
Series:RSC biomolecular sciences.
Subjects:
Oligonucleotides > therapeutic use.
Oligonucleotides > Therapeutic use.
MEDICAL > Pharmacology.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • The role of backbone modifications in oligonucleotide-based strategies
  • Genasense (G3139) : an antisense Bcl-2 oligodeoxyribonucleotide with substantial clinical activity and a complex mechanism of action
  • Antisense morpholino oligomers and their peptide conjugates
  • Peptide-peptide nucleic acid conjugates for modulation of gene expression
  • Locked nucleic acid: properties and therapeutic aspects
  • Immune stimulatory oligonucleotides
  • Decoy oligodeoxynucleotides to treat inflammatory diseases
  • AS1411 : development of an anticancer aptamer
  • Spiegelmer NOX-E36 for renal diseases
  • Strategies for the delivery of oligonucleotides in vivo
  • Lipid-mediated in vivo delivery of small interfering RNAs
  • Vector-mediated and viral delivery of short hairpin RNAs
  • Development of an RNAi-based gene therapy against HIV-1
  • RNA based therapies for treatment of HIV infection.