Table of Contents:
  • Ribozymes and RNA catalysis : introduction and primer
  • Proton transfer in ribozyme catalysis
  • Finding the Hammerhead ribozyme active site
  • Hammerhead ribozyme crystal structures and catalysis
  • The Hairpin and Varkud satellite ribozymes
  • Catalytic mechanism of the HDV ribozyme
  • Mammalian self-cleaving ribozymes
  • The structure and action of glmS ribozymes
  • A structural analysis of Ribonuclease P
  • Group I introns : biochemical and crystallographic characterization of the active site structure
  • Group II introns : catalysts for splicing, genomic change and evolution
  • The GIR1 branching ribozyme
  • Is the spliceosome a ribozyme?
  • Peptidyl transferase mechanism : the ribosome as a ribozyme
  • Folding mechanisms of Group I ribozymes.