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From DNA photolesions to mutations, skin cancer and cell death /

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As modern day society takes an increasing interest in outdoor activities, its exposure to sunlight has never been greater. As a consequence, countries throughout the world are experiencing a dramatic increase in the incidences of skin carcinomas and melanomas. From DNA photolesions to mutations, ski...

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Bibliographic Details
Other Authors: Drouin, Régen, 1958-, Rouabhia, Mahmoud, 1957-, Sage, Evelyne
Format: eBook
Language:English
Published: Cambridge, UK : Royal Society of Chemistry, [2005]
Series:Comprehensive series in photochemistry & photobiology ; v. 5.
Subjects:
Skin Neoplasms > etiology.
Skin Physiological Phenomena > genetics.
Ultraviolet Rays > adverse effects.
Atmosphere.
Biochemical Phenomena.
Biological Phenomena.
Chemical Phenomena.
DNA Damage.
DNA Repair.
Delivery of Health Care.
Disease.
Ecological and Environmental Phenomena.
Electromagnetic Phenomena.
Environment and Public Health.
Environment.
Genetic Phenomena.
Integumentary System Physiological Phenomena.
Light.
Meteorological Concepts.
Neoplasms by Site.
Neoplasms.
Optical Phenomena.
Physical Phenomena.
Radiation, Nonionizing.
Radiation.
Skin Diseases.
Skin Neoplasms.
Skin Physiological Phenomena.
Skin and Connective Tissue Diseases.
Sunlight.
Ultraviolet Rays.
Weather.
Skin > Cancer.
Chemistry.
HEALTH & FITNESS > Diseases > Cancer.
MEDICAL > Oncology.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • UVB and UVA induced formation of photoproducts within cellular DNA
  • Chemical sequencing profiles of photosensitized DNA damage
  • DNA damage induced by UVA radiation : role in solar mutagenesis
  • Mutations induced by UV and sunlight
  • Mechanisms and mutagenic consequences of photoproduct bypass by replicative and DNA damage bypass polymerases
  • The Ogg1 protein of Saccharomyces cerevisiae: properties and biological functions
  • The role of a yeast homologue of the human phosphatase activator hPTPA in the cellular response to oxidative DNA damage
  • DNA repair in RNA polymerase I transcribed genes
  • Global genome nucleotide excision repair: key players and their functions
  • Efficient repair of UV-induced DNA damage in terminally differentiated human keratinocytes
  • Reactivation of UV-damaged viruses and reporter genes in mammalian cells
  • Transcription of p53-regulated genes under transcriptional stress : implications for nucleotide excision repair
  • What a difference a wavelength makes : the role of p53 in nucleotide excision repair of UV-induced DNA damage
  • p53 and p33ING1 : Role in nucleotide excision repair of UV-damaged DNA
  • Nuclear and non-nuclear signals leading to UV-induced apoptosis
  • Opposing roles of UV-induced apoptosis in early skin cancer
  • Acquired activation of signalling pathways in skin tumours from DNA repair-deficient xeroderma pigmentosum patients
  • Chaos theory and self-organized criticality describe the DNA damage signal transduction network.