Cover Image

Nutritional Signaling Pathway Activities in Obesity and Diabetes.

This book disseminates the cutting-edge knowledge pertaining to nutritional signaling activities in obesity and diabetes, including the regulatory mechanisms and perspectives of nutritional interventions for disease prevention.

Bibliographic Details
Other Authors: Cheng, Zhiyong
Format: eBook
Language:English
Published: Cambridge : Royal Society of Chemistry, 2020.
Series:Food chemistry, function and analysis ; no. 24.
Subjects:
Cellular signal transduction.
Metabolism > Disorders.
Metabolism.
Nutrition.
Electronic books.
Online Access:Connect to the full text of this electronic book
Connect to the full text of this electronic book
Table of Contents:
  • Cover
  • Half-title
  • Series information
  • Title page
  • Copyright information
  • Preface
  • Table of contents
  • Chapter 1 Diabetes and Obesity: An Overview of Nutritional Effects
  • 1.1 Introduction
  • 1.2 Mechanisms of Insulin Resistance and Metabolic Syndrome
  • 1.3 Prevention Trials
  • 1.4 Adherence
  • 1.5 Dietary Components Affecting T2D
  • 1.5.2 Fiber
  • 1.5.3 Glycemic Index and Load
  • 1.6 Dietary Interventions in T2D
  • 1.6.1 Mediterranean Diet
  • 1.6.2 The New Nordic Diet
  • 1.6.3 The Ornish Diet
  • 1.6.4 Ketogenic Diet
  • 1.7 Micronutrients
  • 1.7.1 Chromium
  • 1.7.2 Selenium
  • 1.7.3 Vitamin D
  • 1.7.4 Cinnamon
  • 1.8 Plant Alkaloids
  • 1.9 Future Directions
  • References
  • Chapter 2 Maternal Nutrition and the Risk of Obesity and Diabetes in the Offspring
  • 2.1 Introduction
  • 2.2 Evidence from Epidemiology and Human Studies
  • 2.3 Evidence from Experimental Animal Models
  • 2.3.1 Global Nutrient Restriction
  • 2.3.2 Protein Restriction
  • 2.3.3 Maternal Obesity
  • 2.3.4 Micronutrient Deficiencies
  • 2.3.5 Other Models
  • 2.4 Epigenetic Mechanisms
  • 2.5 Intervention Strategies
  • 2.6 Conclusions
  • References
  • 4.4.4 AMPK-FOXOs-NF-.B Signaling Pathway
  • 4.4.5 PGC-1a/PPAR.-NF-.B Signaling Pathway
  • 4.4.6 mTOR Signaling Pathway
  • 4.4.7 The Roles of TLRs and NLRPs in Inflammation
  • 4.5 Conclusion
  • References
  • Chapter 5 The Interaction of Nutrition with Nuclear Receptors in Obesity and Diabetes
  • 5.1 Introduction
  • 5.2 Metabolic Nuclear Receptors
  • 5.2.1 The Interaction of Nutrition with Nuclear Receptors
  • 5.2.2 Interaction of Nutrients with Metabolic Nuclear Receptors in Different Tissues During Obesity and Diabetes
  • 5.3 Intestine
  • 5.3.1 Physiological Role of FXR on Bile Acid (BA) Homeostasis and Hormone Secretion in the Intestine
  • Acknowledgement
  • References
  • Chapter 4 Nutritional Regulation of Inflammation in Obesity and Diabetes
  • 4.1 Introduction
  • 4.2 Nutritional Regulation of Adipocytes in Obesity and Type 2 Diabetes
  • 4.3 Nutritional Regulation of Nutrition on Immune Cells in Obesity and Type 2 Diabetes
  • 4.4 Nutritional Regulation of Inflammatory Signaling Pathways in Obesity and Type 2 Diabetes
  • 4.4.1 5' Adenosine Monophosphate-activated Protein Kinase (AMPK) as a Central Energy Sensor
  • 4.4.2 NF-.B Signaling Pathways as an Inflammatory Switch
  • 4.4.3 AMPK-SIRT1-NF-.B Signaling Pathway
  • Chapter 3 Lessons Learned from Recent Clinical Trials Targeting Diets to Treat and Prevent Obesity and Diabetes
  • 3.1 Introduction
  • 3.2 Current Issues in Diabetes and Obesity Research
  • 3.3 Results from Reviews on Obesity and Diabetes
  • 3.3.1 Limitations of Interpreting Review Data
  • 3.3.2 Low-fat Diets
  • 3.3.2.1 Clinical Trials
  • 3.3.2.2 Potential Mechanisms of Low-fat Diets
  • 3.3.3 Low-carbohydrate Diets
  • 3.3.3.1 Clinical Trials
  • 3.3.3.2 Potential Mechanisms of Low-carbohydrate Diets
  • 3.4 Challenges with Diets as Interventions and Suggestions for the Future
  • 3.5 Summary