http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Continuous crystallization is an area of intense research, with particular respect to the pharmaceutical industry and fine chemicals. Improvements in continuous crystallization technologies offer chemical industries significant financial gains, through reduced expenditure and operational costs, and consistent product quality. Written by well-known leaders in the field, The Handbook of Continuous Crystallization presents fundamental and applied knowledge, with attention paid to application and scaling up, and the burgeoning area of process intensification. Beginning with concepts around crystallization techniques and control strategies, the reader will learn about experimental methods and computational tools. Case studies spanning fine and bulk chemicals, the pharmaceutical industry, and employing new mathematical tools, put theory into context.
Intro -- Half title -- Title -- Copyright -- Preface -- Contents -- Chapter 1 Nucleation and Crystal Growth in Continuous Crystallization -- 1.1 Introduction -- 1.2 Crystal Nucleation -- 1.2.1 Primary Nucleation -- 1.2.2 Secondary Nucleation -- 1.3 Continuous Crystallization -- 1.3.1 Crystalline Product Quality Attributes -- 1.3.2 Continuous Heterogeneous Crystallization on Excipient Surfaces -- 1.3.3 Agitated Vessel Type Crystallization Process -- 1.3.4 Plug Flow Type Crystallization Process -- 1.4 Continuous Seeding and Nucleators -- 1.4.1 Continuous Seeding
1.4.2 Decoupling Nucleation and Growth in Continuous Crystallization -- 1.4.3 Continuous Nucleators -- 1.4.4 Supersaturation Control by Rapid or Non-rapid Mixing -- 1.4.5 Ultrasound Induced Nucleation -- 1.4.6 Fully Continuous Crystallization in an MSMPR Cascade -- 1.4.7 Continuous MSMPR Cascade with Batch Crystallization Start Up -- 1.4.8 High Shear Wet Mill in MSMPR Configuration -- 1.4.9 Secondary Nucleators -- References -- Chapter 2 Fundamentals of Population Balance Based Crystallization Process Modeling -- 2.1 Introduction -- 2.2 Modeling of Fundamental Crystallization Mechanisms
2.2.1 The Supersaturation -- 2.2.2 Nucleation -- 2.2.3 Growth and Dissolution -- 2.2.4 Modeling Crystal Agglomeration -- 2.2.5 Modeling Crystal Breakage -- 2.3 Modeling the MSMPR Crystallizer -- 2.3.1 MSMPR Crystallizer Configurations -- 2.4 Modeling the Tubular Crystallizer -- 2.4.1 Case Study: PFC With Multiple Feeding Points -- 2.5 Numerical Solution Methods for the Population Balance Equations -- 2.5.1 Moment Based Methods -- 2.5.2 Method of Characteristics -- 2.5.3 Finite Volume Methods -- 2.6 Advanced Crystallization Modeling -- Case Studies
2.6.1 Modeling Solvent Mediated Polymorphic Transformation -- 2.6.2 Modeling Preferential Crystallization of Enantiomers -- 2.7 The Growth Rate Dispersion (GRD) -- References -- Chapter 3 Continuous Crystallisation With Oscillatory Baffled Crystalliser Technology -- 3.1 Introduction -- 3.2 Plug Flow -- 3.2.1 The Definition -- 3.2.2 How to Measure Plug Flow -- 3.2.3 How Could Near Plug Flow Be Achieved in the Real World? -- 3.3 Continuous Oscillatory Baffled Crystalliser -- 3.3.1 Principles -- 3.3.2 Mixing Evaluation in Single Phase -- 3.3.3 Mixing Evaluation in Two Phases
3.3.4 Moving Fluid vs. Moving Baffles -- 3.3.5 Scaling Up and Down -- 3.3.6 Power Dissipation -- 3.4 Design and Operation of Continuous Oscillatory Baffled Crystalliser -- 3.4.1 Linking the Design and Operation With Science -- 3.5 What Has Been Done? -- 3.5.1 Cooling Crystallisation -- 3.5.2 Antisolvent Crystallisation and Seed Generator -- 3.5.3 Nucleation by Scraping -- 3.5.4 Encrustation -- 3.5.5 PAT Implementation -- 3.6 What Are the Opportunities and Challenges? -- 3.6.1 Reactive Crystallisation -- 3.6.2 Co-crystallisation -- 3.6.3 Crystallisation of Energetic Materials
edited by Nima Yazdanpanah, Massachusetts Institute of Technology, USA and Zoltan K. Nagy, Purdue University, USA.
Includes bibliographical references and index.