Nanoparticle-protein corona : biophysics to biology /
Providing a detailed understanding of nanoparticle-protein corona formation, its biological significance and the factors that governs the formation of corona, this book will be of interest to researchers studying the applications of nanoparticles as well as toxicologists and pharmaceutical chemists.
| Other Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
London :
Royal Society of Chemistry,
2019.
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| Series: | Issues in toxicology.
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Cover; Nanoparticle-Protein Corona: Biophysics to Biology; Preface; Contents; Chapter 1
- Nanoparticle-Protein Corona Complex: Composition, Kinetics, Physico-Chemical Characterization, and Impact on Biomedical Applications; 1.1 Introduction; 1.2 Physico-Chemical Parameters of NPs Controlling Protein Corona Formation; 1.2.1 Protein Corona Composition Varies with NP Type; 1.2.2 Effect of NP Size Over Protein Corona Formation; 1.2.3 Effect of NP Shape on Protein Corona Formation; 1.2.4 Effect of Hydrophobicity and Hydrophilicity on Protein Corona Formation
- 1.2.5 Effect of a NP's Surface Charge on Protein Corona Formation1.2.6 Effect of Temperature on Protein Corona Formation Over NPs; 1.2.7 Effect of pH on Protein Corona Formation; 1.2.8 Effect of Surface Modification of NPs and Protein Corona Formation; 1.3 Composition of the Protein Corona; 1.4 Kinetics of Protein Corona Formation; 1.5 Common Techniques to Characterize Protein Coronas on NPs; 1.5.1 UV-visible Spectroscopy; 1.5.2 Fourier-transform Infrared Spectroscopy; 1.5.3 Dynamic Light Scattering and Zeta Potential; 1.5.4 Isothermal Titration Calorimetry
- 1.5.5 Circular Dichroism Spectroscopy1.6 Applications of Protein Coronas; 1.6.1 Role of the Protein Corona Towards Targeted Drug Delivery; 1.6.2 Engineering Nanoparticle-Protein Technologies for Early Cancer Detection; 1.6.3 Toxicity Reduction; 1.7 Limitations and Future Perspectives; Acknowledgements; References; Chapter 2
- Biological Significance of the Nanoparticles Protein Corona; 2.1 Introduction; 2.2 Formation of a Protein Corona; 2.2.1 Parameters Involved in the Formation of the Protein Corona; 2.2.1.1 Nanoparticles' Intrinsic Parameters; 2.2.1.2 Biological Environmental Factors
- 2.3 Impact of the Protein Corona on the Nanoparticle's Physicochemical Properties2.4 Consequences of the Protein Corona on Nanoparticles' Biological Fate and Outcomes; 2.4.1 Impact of the Protein Corona on the Nanoparticles' Biological Fate; 2.4.1.1 Impact of the Protein Corona on Nanoparticle-Cell Interactions; 2.4.1.2 Impact of the Protein Corona on the Nanoparticles' Uptake by Cells; 2.4.1.3 Impact of the Protein Corona on the Nanoparticles' Biodistribution, Clearance and Targeting; 2.4.2 Impact of the Protein Corona on the Nanoparticles' Biological Outcomes
- 2.4.2.1 Impact of the Protein Corona on the Nanoparticles' Toxicity2.4.2.2 Impact of the Protein Corona on the Immune Response to Nanoparticles; 2.4.2.3 Alteration of Protein Conformation Following Their Adsorption on a Nanoparticle Surface and Impact of the Protein Corona ... ; 2.5 Issues Associated with the Protein Corona; 2.5.1 Complexity of the Protein Corona; 2.5.2 Discrepancies Between In Vitro and In Vivo Data; 2.6 Conclusion and Perspectives; References; Chapter 3
- Factors Affecting a Nanoparticle's Protein Corona Formation; 3.1 Introduction