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Biomaterial control of therapeutic stem cells /

Using this book, the reader will gain a robust overview of current research and a clearer understanding of the status of clinical trials for stem cell therapies.

Bibliographic Details
Main Author: Higuchi, Akon, 1956- (Author)
Format: eBook
Language:English
Published: London : Royal Society of Chemistry, [2019]
Series:Biomaterials science series ; 4.
Subjects:
Stem Cell Transplantation > methods.
Stem Cells.
Biocompatible Materials > therapeutic use.
Organ Culture Techniques > methods.
Regenerative Medicine.
Tissue Engineering > methods.
Biomedical materials.
Stem cells > Therapeutic use.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • 1.1 Introduction
  • 1.2 Stem Cells
  • 1.3 The Extracellular Matrix
  • 1.4 hPSC Culture on Biomaterials
  • 1.5 hPSC Differentiation on Biomaterials
  • 1.6 Biomaterials Control hPS Cell Differentiation Fate
  • 1.7 Stem Cell Therapy Using Biomaterials
  • References
  • Chapter 2. Adult Stem Cell Culture on Extracellular Matrices and Natural Biopolymers
  • 2.1 Introduction
  • 2.2 Chemical and Biological Interactions of ECM Proteins and Stem Cells
  • 2.3 Collagen
  • 2.3.1 Collagen Type I Scaffold
  • 2.3.2 Organic Hybrid Scaffold Made of Collagen Type I2.3.3 Scaffolds Using Collagen Type II and Type III
  • 2.3.4 Hybrid Collagen Scaffold Using Inorganic Materials
  • 2.3.5 Collagen Scaffolds Immobilized Antibody Targeting Stem Cells
  • 2.3.6 Differentiation into Endoderm and Ectoderm Lineages Using Collagen Scaffolds
  • 2.4 Gelatin
  • 2.4.1 Gelatin Hydrogels and Scaffolds
  • 2.4.2 Gelatin Hybrid Scaffolds
  • 2.5 Laminin
  • 2.6 Fibronectin
  • 2.7 Vitronectin
  • 2.8 Fibrin
  • 2.9 Decellularized ECM
  • 2.10 Biomaterials with ECM-mimicking Oligopeptides
  • 2.10.1 MS Cell Differentiation on Self-assembled ECM-peptide Nanofibers2.10.2 Osteogenic Induction on ECM-peptide Immobilized Dishes and Scaffolds
  • 2.10.3 Chondrogenic Induction on ECM-peptide Immobilized Dishes and Scaffolds
  • 2.10.4 Neural Induction on ECM-peptide Immobilized Dishes and Scaffolds
  • 2.11 Biomaterials with N-Cadherin Mimicking Oligopeptides
  • 2.12 Conclusion and Future Perspective
  • References
  • Chapter 3. Feeder-free and Xeno-free Culture of Human Pluripotent Stem Cells on Biomaterials
  • 3.1 Introduction
  • 3.2 Analysis of the Pluripotency of hPS Cells
  • 3.3 2D Cultivation of hPS Cells on Biomaterials3.3.1 hPS Cell Cultivation on ECM-immobilized Surfaces in 2D
  • 3.3.2 hPS Cell Cultivation on Oligopeptide-immobilized Surfaces in 2D
  • 3.3.3 hPS Cell Cultivation on a Recombinant E-cadherin Surface in 2D
  • 3.3.4 hPS Cell Cultivation on Biomaterials Immobilized with Polysaccharide in 2D
  • 3.3.5 hPS Cell Cultivation on Synthetic Biomaterials in 2D
  • 3.4 Three-dimensional Cultivation of hPS Cells on Biomaterials
  • 3.4.1 The 3D Cultivation of hPS Cells on Microcarriers
  • 3.4.2 The 3D Cultivation of hPS Cells Embedded in Hydrogels (Microcapsules)
  • 3.5 hPS Cell Cultivation on PDL-coated Dishes with Small Molecules3.6 Conclusion and Future Perspectives
  • Acknowledgements
  • References
  • Chapter 4. Differentiation Fates of Human ES and iPS Cells Guided by Physical Cues of Biomaterials
  • 4.1 Introduction
  • 4.2 Induction Protocols of Human Pluripotent Stem Cells
  • 4.2.1 EB Formation
  • 4.2.2 Induction of hPS Cells by EB Generation
  • 4.2.3 Induction of hPS Cells Seeded on Materials Directly
  • 4.3 Physical Cues of Materials in hPS Cell Induction
  • 4.3.1 Effect of Elasticity of Cell Cultivation Biomaterials on Stem Cell Induction
  • 3.2 Topographic Effects of Biomaterials on the Differentiation Fates of hPS Cells
  • 4.3.3 Stem Cell Induction on Nanofibers
  • 4.3.4 Effect of Electrical and Mechanical
  • Forces of Biomaterials on Induction Fate of hPS Cells
  • 4.4 Conclusions and Perspectives
  • References
  • Chapter 5. Biomaterial Control of Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
  • 5.1 Introduction
  • 5.2 Induction of hPS Cells into Neural Lineages
  • 5.2.1 Stromal-induced Differentiation into Neural Lineages
  • 5.2.2 Induction into Neural Lineages Through EB Generation
  • 5.2.3 Direct Induction into Neural Lineages on Materials with No EB Generation
  • 5.2.4 Effect of Cell Cultivation Materials on hPS Cell Induction into Neural Lineages
  • 5.3 Induction of hPS Cells into Cardiomyocytes
  • 5.3.1 Efficient Protocols for Inducing hPS
  • Cells into Cardiomyocyte
  • 5.3.2 Effect of Cell Cultivation Materials on hPS Cell Induction into Cardiomyocytes
  • 5.4 Induction into Hepatocytes
  • 5.4.1 Efficient Protocols for hPS Cell Induction into Hepatocytes on Materials
  • 5.4.2 3D Cultivation Facilitates the Induction of hPS Cells into Hepatocytes
  • 5.4.3 Effect of Cell Culture Biomaterials on hPS Cell Differentiation into Hepatocytes
  • 5.5 Differentiation into Insulin-secreting b Cells
  • 5.6 Conclusions and Perspectives
  • References
  • Chapter 6. Clinical Trials of Stem Cell Therapies Using Biomaterials
  • 6.1 Introduction
  • 6.2 Stem Cell Therapy for Myocardial Infarction (MI) in Clinical Trials
  • 6.2.1 Clinical Therapies for MI Using hES cells
  • 6.2.2 Clinical Therapy for MI Using Fetal and Adult Stem Cells
  • 6.2.3 Future Trends of MI Therapy Using Stem Cells
  • 6.3 Stem Cell Therapy for Macular Degeneration Disease in Clinical Trials
  • 6.3.1 Macular Degeneration Diseases and Eye Structure
  • 6.3.2 Bioengineering in Stem Cell Therapies for Macular Degeneration Diseases
  • 6.3.3 Biomaterial Assists in the Therapies for Macular Degeneration Diseases
  • 6.3.4 Bioengineering for Clinical Trials Using hES Cell-derived RPE Cells
  • 6.3.5 Bioengineering for Clinical Trials Using hiPS Cell-derived RPE Sheets
  • 6.3.6 Bioengineering for Clinical Trials Using Adult Stem Cells
  • 6.3.7 Clinical Trials Using Fetal Stem Cells
  • 6.3.8 Future Perspectives of Stem Cell Therapy for Macular Degeneration Diseases
  • References
  • Chapter 7. Conclusions and Future Perspective on Biomaterial Control of Therapeutic Stem Cells.