http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Stimuli-responsive drug delivery systems
This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials.
Cover; Stimuli-responsive Drug Delivery Systems; Preface; Dedication; Contents; Chapter 1 -- Fundamentals of Stimuli-responsive Drug and Gene Delivery Systems; 1.1 Introduction; 1.2 pH-Sensitive DDS; 1.3 Redox Potential-sensitive DDS; 1.4 Enzyme-sensitive DDS; 1.5 Thermo-sensitive DDS; 1.6 Magnetically-sensitive DDS; 1.7 Ultrasound-sensitive DDS; 1.8 Light-sensitive DDS; 1.9 Stimuli-sensitive DDS for Combination Therapy: Case of Cancer; 1.10 Concluding Remarks; References; Chapter 2 -- Materials and Chemistry of Stimuli-responsive Drug Delivery Systems; 2.1 Introduction; 2.2 Physical Stimuli
2.2.1 Thermoresponsive Materials2.2.2 Photoresponsive Materials; 2.2.2.1 Photoisomerizable Groups; 2.2.2.2 Photo-cleavable Groups; 2.2.3 Magnetically Responsive Materials; 2.3 Chemical Stimuli; 2.3.1 pH Responsive Materials; 2.3.2 Thiol-responsive Materials; 2.4 Biological/Biochemical Stimuli; 2.5 Summary; References; Chapter 3 -- pH-responsive Drug Delivery Systems; 3.1 Introduction; 3.1.1 pH Environment in Gastrointestinal Organs; 3.1.2 Acidic pH Environment in Pathological Tissues; 3.1.3 Acidic Subcellular Organelles; 3.2 Classification of pH-responsive Materials
3.2.1 Polymers with Ionizable Functional Groups3.2.1.1 pH-responsive Acidic Polymers; 3.2.1.2 pH-responsive Basic Polymers; 3.2.1.3 pH-responsive Natural Polymers; 3.2.2 Acid-labile pH-sensitive Nanocarriers; 3.2.3 pH-responsive Inorganic Nanoscale Materials; 3.3 Release Mechanism of pH-responsive DDS; 3.3.1 Hydrophobic-Hydrophilic Transition Induced Disassembly; 3.3.2 Cleavage of Acid-labile Linkers for Drug Release; 3.3.3 Gel Swelling; 3.3.4 Cap/Coating Removal; 3.3.5 Gas Generation; 3.4 pH-responsive DDS for Targeted Delivery; 3.4.1 PEG Shedding; 3.4.2 Ligand Shielding/Deshielding
3.4.3 Ligand Pop-up Targeting3.4.4 Charge Reversal; 3.4.5 Size Change; 3.4.6 Membrane Fusion by pH-sensitive Peptides; 3.4.6.1 pH-(Low) Insertion Peptide (pHLIP); 3.4.6.2 pH-activatable Cell-penetrating Peptides CPPs; 3.5 pH-responsive DDS for Intracellular Delivery; 3.6 Conclusions; References; Chapter 4 -- Thermo-responsive Nanomedicines for Drug Delivery in the Gastrointestinal Tract; 4.1 Introduction; 4.2 Gastrointestinal Tract; 4.2.1 Constitution of the Gastrointestinal Tract; 4.2.2 Differences Between Normal and Diseased Tissues; 4.2.3 Inflammatory Bowel Disease
4.2.4 Gastric and Colorectal Cancer4.3 Thermo-responsive Materials and Nanocarrier Systems; 4.3.1 Thermo-responsive Polymeric Nanoparticles; 4.3.2 Thermo-responsive Liposomes; 4.3.3 Thermo-responsive Micelles; 4.4 Conclusions and Future Perspectives; Acknowledgements; References; Chapter 5 -- Redox-responsive Drug Delivery Systems; 5.1 Redox-responsive Drug Delivery Systems; 5.1.1 Redox Profile of the Tumor Microenvironment and the Cancer Cell; 5.1.1.1 Reactive Oxygen Species; 5.1.1.2 Glutathione; 5.1.1.3 Redox Potential in Cancer Cell; 5.1.2 Reduction (Glutathione)-responsive Systems