http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
from basic research to clinical practice
1 online resource (xxi, 570 pages) : illustrations
Provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field.
Anti-Aging Drugs: Where are We and Where are We Going? / Alexander M. Vaiserman and Oleh V. Lushchak -- Aging: Natural or Disease? A View from Medical Textbooks / S. Janac, B. Clarke and D. Gems -- The Search for the "Anti-Aging Pill": A Critical Viewpoint / Éric le Bourg -- Testing of Geroprotectors in Experiments on Cell Cultures: Pros and Cons / Alexander N. Khokhlov and Galina V. Morgunova -- Pharmacogenomics and Epigenomics of Age-Related Neurodegenerative Disorders: Strategies for Drug Development / Ramón Cacabelos, Juan Carlos Carril and Oscar Teijido -- Nanotechnology in Anti-Aging: Nutraceutical Delivery and Related Applications / Anila Mathew, Francesco Marotta and D. Sakthi Kumar -- Hormetins as Drugs for Healthy Aging / Suresh I.S. Rattan -- Antioxidant Therapy of Aging: From Free Radical Chemistry to Systems Theory of Reliability / V.K. Koltover -- Mitochondria-Targeted Rechargeable Antioxidants as Potential Anti-Aging Drugs / Elena G. Pasyukova, Boris A. Feniouk and Vladimir P. Skulachev -- Mimetics of Caloric Restriction / Oleh Lushchak and Dmytro Gospodaryov -- Allosteric SIRT1 Activators as Putative Anti-Aging Drugs / Basil P. Hubbard -- Therapeutic Potential of Sirtuin Inhibitors in Cancer / Francisco Javier Alcain, Consuelo M. Nieva, Lucía Fernández del Río, Raquel Santiago-Mora, Elena Gutiérrez-Casado, Mario Duran-Prado and Jose M. Villalba -- Lifespan-Extending Effect of Resveratrol and Other Phytochemicals / Shin-Hae Lee and Kyung-Jin Min -- Extending Lifespan by Inhibiting the Mechanistic Target of Rapamycin (mTOR) / Dudley W. Lamming -- mTOR, Aging and Cancer: Prospects for Pharmacological Interventions / Z.D. Sharp -- Anti-Aging Action of PPARs: Potential Therapeutic Targets / Ki Wung Chung, Byung Pal Yu and Hae Young Chung -- Antidiabetic Biguanides as Anti-Aging Drugs / Vladimir N. Anisimov -- S-Adenosylmethionine Metabolism: A Promising Avenue in Anti-Aging Medicine? / W.A.M. Loenen -- Melatonin as a Geroprotector: Healthy Aging vs. Extension of Lifespan / R. Hardeland -- Short Peptides Regulate Gene Expression, Protein Synthesis and Enhance Life Span / Vladimir Khavinson and Irina Popovich -- HDAC Inhibitors: A New Avenue in Anti-Aging Medicine / E.G. Pasyukova and A.M. Vaiserman -- Human Life Extension: Opportunities, Challenges, and Implications for Public Health Policy / Ilia Stambler.
Includes bibliographical references and index.