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The handbook of continuous crystallization /

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Bibliographic Details
Corporate Author: ProQuest (Firm)
Other Authors: Yazdanpanah, Nima (Editor), Nagy, Zoltan K. (Editor)
Format: eBook
Language:English
Published: London : The Royal Society of Chemistry, 2020.
Subjects:
Crystallization.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Intro
  • Half title
  • Title
  • Copyright
  • Preface
  • Contents
  • Chapter 1 Nucleation and Crystal Growth in Continuous Crystallization
  • 1.1 Introduction
  • 1.2 Crystal Nucleation
  • 1.2.1 Primary Nucleation
  • 1.2.2 Secondary Nucleation
  • 1.3 Continuous Crystallization
  • 1.3.1 Crystalline Product Quality Attributes
  • 1.3.2 Continuous Heterogeneous Crystallization on Excipient Surfaces
  • 1.3.3 Agitated Vessel Type Crystallization Process
  • 1.3.4 Plug Flow Type Crystallization Process
  • 1.4 Continuous Seeding and Nucleators
  • 1.4.1 Continuous Seeding
  • 1.4.2 Decoupling Nucleation and Growth in Continuous Crystallization
  • 1.4.3 Continuous Nucleators
  • 1.4.4 Supersaturation Control by Rapid or Non-rapid Mixing
  • 1.4.5 Ultrasound Induced Nucleation
  • 1.4.6 Fully Continuous Crystallization in an MSMPR Cascade
  • 1.4.7 Continuous MSMPR Cascade with Batch Crystallization Start Up
  • 1.4.8 High Shear Wet Mill in MSMPR Configuration
  • 1.4.9 Secondary Nucleators
  • References
  • Chapter 2 Fundamentals of Population Balance Based Crystallization Process Modeling
  • 2.1 Introduction
  • 2.2 Modeling of Fundamental Crystallization Mechanisms
  • 2.2.1 The Supersaturation
  • 2.2.2 Nucleation
  • 2.2.3 Growth and Dissolution
  • 2.2.4 Modeling Crystal Agglomeration
  • 2.2.5 Modeling Crystal Breakage
  • 2.3 Modeling the MSMPR Crystallizer
  • 2.3.1 MSMPR Crystallizer Configurations
  • 2.4 Modeling the Tubular Crystallizer
  • 2.4.1 Case Study: PFC With Multiple Feeding Points
  • 2.5 Numerical Solution Methods for the Population Balance Equations
  • 2.5.1 Moment Based Methods
  • 2.5.2 Method of Characteristics
  • 2.5.3 Finite Volume Methods
  • 2.6 Advanced Crystallization Modeling
  • Case Studies
  • 2.6.1 Modeling Solvent Mediated Polymorphic Transformation
  • 2.6.2 Modeling Preferential Crystallization of Enantiomers
  • 2.7 The Growth Rate Dispersion (GRD)
  • References
  • Chapter 3 Continuous Crystallisation With Oscillatory Baffled Crystalliser Technology
  • 3.1 Introduction
  • 3.2 Plug Flow
  • 3.2.1 The Definition
  • 3.2.2 How to Measure Plug Flow
  • 3.2.3 How Could Near Plug Flow Be Achieved in the Real World?
  • 3.3 Continuous Oscillatory Baffled Crystalliser
  • 3.3.1 Principles
  • 3.3.2 Mixing Evaluation in Single Phase
  • 3.3.3 Mixing Evaluation in Two Phases
  • 3.3.4 Moving Fluid vs. Moving Baffles
  • 3.3.5 Scaling Up and Down
  • 3.3.6 Power Dissipation
  • 3.4 Design and Operation of Continuous Oscillatory Baffled Crystalliser
  • 3.4.1 Linking the Design and Operation With Science
  • 3.5 What Has Been Done?
  • 3.5.1 Cooling Crystallisation
  • 3.5.2 Antisolvent Crystallisation and Seed Generator
  • 3.5.3 Nucleation by Scraping
  • 3.5.4 Encrustation
  • 3.5.5 PAT Implementation
  • 3.6 What Are the Opportunities and Challenges?
  • 3.6.1 Reactive Crystallisation
  • 3.6.2 Co-crystallisation
  • 3.6.3 Crystallisation of Energetic Materials