http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Intro -- Half title -- Title -- Copyright -- Preface -- Contents -- Chapter 1 Nucleation and Crystal Growth in Continuous Crystallization -- 1.1 Introduction -- 1.2 Crystal Nucleation -- 1.2.1 Primary Nucleation -- 1.2.2 Secondary Nucleation -- 1.3 Continuous Crystallization -- 1.3.1 Crystalline Product Quality Attributes -- 1.3.2 Continuous Heterogeneous Crystallization on Excipient Surfaces -- 1.3.3 Agitated Vessel Type Crystallization Process -- 1.3.4 Plug Flow Type Crystallization Process -- 1.4 Continuous Seeding and Nucleators -- 1.4.1 Continuous Seeding
1.4.2 Decoupling Nucleation and Growth in Continuous Crystallization -- 1.4.3 Continuous Nucleators -- 1.4.4 Supersaturation Control by Rapid or Non-rapid Mixing -- 1.4.5 Ultrasound Induced Nucleation -- 1.4.6 Fully Continuous Crystallization in an MSMPR Cascade -- 1.4.7 Continuous MSMPR Cascade with Batch Crystallization Start Up -- 1.4.8 High Shear Wet Mill in MSMPR Configuration -- 1.4.9 Secondary Nucleators -- References -- Chapter 2 Fundamentals of Population Balance Based Crystallization Process Modeling -- 2.1 Introduction -- 2.2 Modeling of Fundamental Crystallization Mechanisms
2.2.1 The Supersaturation -- 2.2.2 Nucleation -- 2.2.3 Growth and Dissolution -- 2.2.4 Modeling Crystal Agglomeration -- 2.2.5 Modeling Crystal Breakage -- 2.3 Modeling the MSMPR Crystallizer -- 2.3.1 MSMPR Crystallizer Configurations -- 2.4 Modeling the Tubular Crystallizer -- 2.4.1 Case Study: PFC With Multiple Feeding Points -- 2.5 Numerical Solution Methods for the Population Balance Equations -- 2.5.1 Moment Based Methods -- 2.5.2 Method of Characteristics -- 2.5.3 Finite Volume Methods -- 2.6 Advanced Crystallization Modeling -- Case Studies
2.6.1 Modeling Solvent Mediated Polymorphic Transformation -- 2.6.2 Modeling Preferential Crystallization of Enantiomers -- 2.7 The Growth Rate Dispersion (GRD) -- References -- Chapter 3 Continuous Crystallisation With Oscillatory Baffled Crystalliser Technology -- 3.1 Introduction -- 3.2 Plug Flow -- 3.2.1 The Definition -- 3.2.2 How to Measure Plug Flow -- 3.2.3 How Could Near Plug Flow Be Achieved in the Real World? -- 3.3 Continuous Oscillatory Baffled Crystalliser -- 3.3.1 Principles -- 3.3.2 Mixing Evaluation in Single Phase -- 3.3.3 Mixing Evaluation in Two Phases
3.3.4 Moving Fluid vs. Moving Baffles -- 3.3.5 Scaling Up and Down -- 3.3.6 Power Dissipation -- 3.4 Design and Operation of Continuous Oscillatory Baffled Crystalliser -- 3.4.1 Linking the Design and Operation With Science -- 3.5 What Has Been Done? -- 3.5.1 Cooling Crystallisation -- 3.5.2 Antisolvent Crystallisation and Seed Generator -- 3.5.3 Nucleation by Scraping -- 3.5.4 Encrustation -- 3.5.5 PAT Implementation -- 3.6 What Are the Opportunities and Challenges? -- 3.6.1 Reactive Crystallisation -- 3.6.2 Co-crystallisation -- 3.6.3 Crystallisation of Energetic Materials
edited by Nima Yazdanpanah, Massachusetts Institute of Technology, USA and Zoltan K. Nagy, Purdue University, USA.
Includes bibliographical references and index.