Polymyxin Antibiotics: From Laboratory Bench to Bedside /
This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researc...
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| Other Authors: | , , |
| Format: | eBook |
| Language: | English |
| Published: |
Cham :
Springer International Publishing : Imprint: Springer,
2019.
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| Edition: | 1st ed. 2019. |
| Series: | Advances in experimental medicine and biology.
1145. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Overview
- Multidrug resistant Gram-negative pathogens: the urgent need for 'old' polymyxins
- Discovery, antibacterial spectrum and chemistry
- Mechanisms of antibacterial activity
- Mechanisms of resistance
- Bioanalysis and stability of polymyxins
- In vitro pharmacodynamics and PK/PD in animals
- Antibacterial susceptibility breakpoints
- Labeling of parenteral products of colistin methanesulfonate
- Meta-analysis of polymyxin use in patients
- Clinical use of colistin
- Clinical use of polymyxin B
- Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations
- Rational combinations with other antibiotics
- Toxicities in patients: management and mechanisms
- Antiendotoxin effect
- Discovery of novel polymyxin-like antibiotics
- Conclusion.