Nanoparticle-protein corona : biophysics to biology /
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Published: |
London :
Royal Society of Chemistry,
2019.
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| Series: | Issues in toxicology.
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Cover; Nanoparticle-Protein Corona: Biophysics to Biology; Preface; Contents; Chapter 1
- Nanoparticle-Protein Corona Complex: Composition, Kinetics, Physico-Chemical Characterization, and Impact on Biomedical Applications; 1.1 Introduction; 1.2 Physico-Chemical Parameters of NPs Controlling Protein Corona Formation; 1.2.1 Protein Corona Composition Varies with NP Type; 1.2.2 Effect of NP Size Over Protein Corona Formation; 1.2.3 Effect of NP Shape on Protein Corona Formation; 1.2.4 Effect of Hydrophobicity and Hydrophilicity on Protein Corona Formation
- 1.2.5 Effect of a NP's Surface Charge on Protein Corona Formation1.2.6 Effect of Temperature on Protein Corona Formation Over NPs; 1.2.7 Effect of pH on Protein Corona Formation; 1.2.8 Effect of Surface Modification of NPs and Protein Corona Formation; 1.3 Composition of the Protein Corona; 1.4 Kinetics of Protein Corona Formation; 1.5 Common Techniques to Characterize Protein Coronas on NPs; 1.5.1 UV-visible Spectroscopy; 1.5.2 Fourier-transform Infrared Spectroscopy; 1.5.3 Dynamic Light Scattering and Zeta Potential; 1.5.4 Isothermal Titration Calorimetry
- 1.5.5 Circular Dichroism Spectroscopy1.6 Applications of Protein Coronas; 1.6.1 Role of the Protein Corona Towards Targeted Drug Delivery; 1.6.2 Engineering Nanoparticle-Protein Technologies for Early Cancer Detection; 1.6.3 Toxicity Reduction; 1.7 Limitations and Future Perspectives; Acknowledgements; References; Chapter 2
- Biological Significance of the Nanoparticles Protein Corona; 2.1 Introduction; 2.2 Formation of a Protein Corona; 2.2.1 Parameters Involved in the Formation of the Protein Corona; 2.2.1.1 Nanoparticles' Intrinsic Parameters; 2.2.1.2 Biological Environmental Factors
- 2.3 Impact of the Protein Corona on the Nanoparticle's Physicochemical Properties2.4 Consequences of the Protein Corona on Nanoparticles' Biological Fate and Outcomes; 2.4.1 Impact of the Protein Corona on the Nanoparticles' Biological Fate; 2.4.1.1 Impact of the Protein Corona on Nanoparticle-Cell Interactions; 2.4.1.2 Impact of the Protein Corona on the Nanoparticles' Uptake by Cells; 2.4.1.3 Impact of the Protein Corona on the Nanoparticles' Biodistribution, Clearance and Targeting; 2.4.2 Impact of the Protein Corona on the Nanoparticles' Biological Outcomes
- 2.4.2.1 Impact of the Protein Corona on the Nanoparticles' Toxicity2.4.2.2 Impact of the Protein Corona on the Immune Response to Nanoparticles; 2.4.2.3 Alteration of Protein Conformation Following Their Adsorption on a Nanoparticle Surface and Impact of the Protein Corona ...; 2.5 Issues Associated with the Protein Corona; 2.5.1 Complexity of the Protein Corona; 2.5.2 Discrepancies Between In Vitro and In Vivo Data; 2.6 Conclusion and Perspectives; References; Chapter 3
- Factors Affecting a Nanoparticle's Protein Corona Formation; 3.1 Introduction