Cover Image

Magnetic nanoparticles for medical diagnostics /

Bibliographic Details
Other Authors: Sandhu, Adarsh (Editor), Handa, H. (Hiroshi), 1946- (Editor)
Format: eBook
Language:English
Published: Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2018]
Series:IOP (Series). Release 5.
IOP expanding physics.
Series in physics and engineering in medicine and biology.
Subjects:
Nanostructures > Magnetic properties.
Nanomedicine.
Diagnostic imaging.
Magnetite Nanoparticles > therapeutic use.
Drug Carriers > therapeutic use.
Diagnostic Imaging.
Nanotechnology.
SCIENCE / Nanoscience.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • 1. Portable magnetic probe for detecting magnetic nanoparticles inside the body
  • 1.1. Sentinel lymph node biopsy
  • 1.2. Use of magnetic nanoparticles for sentinel lymph node biopsy
  • 1.3. Pharmacokinetics of magnetic nanoparticles in the lymphatic system
  • 1.4. Techniques for detecting magnetic nanoparticles
  • 1.5. Portable magnetic probe using a permanent magnet
  • 1.6. Clinical applications
  • 1.7. Conclusions and future prospects
  • 2. Magnetic separation of organelles using magnetic beads
  • 2.1. Introduction
  • 2.2. Magnetic separation of endosomes
  • 2.3. Magnetic separation of exosomes
  • 2.4. Magnetic separation of mitochondria
  • 2.5. Magnetic separation of autophagosomes
  • 2.6. Conclusions and future outlook
  • 3. Development of a new affinity nanobead technology and target isolation of bioactive compounds
  • 3.1. Introduction
  • 3.2. Preparation of SG beads
  • 3.3. Immobilization of DNA to SG beads
  • 3.4. Purification of a transcriptional regulatory factor bound to a specific DNA sequence
  • 3.5. Purification from crude cell extract with SG-DNA beads
  • 3.6. Development of FG beads
  • 3.7. Identification of the direct targets of internal bioactive compounds
  • 3.8. Identification of the direct targets of natural products
  • 3.9. Identification of the direct targets of pharmaceutical drugs
  • 3.10. Identification of a direct target of thalidomide using FG beads
  • 3.11. Functions of CRBN, the common direct primary target of IMiDs and other glutarimide-containing compounds
  • 3.12. Development of a new type of CRBN-based drug
  • 3.13. Conclusions
  • 4. Fluorescent magnetic beads for medical diagnostics
  • 4.1. Introduction
  • 4.2. Production of novel fluorescent magnetic beads (fluorescent ferrite beads; FF beads)
  • 4.3. Functionalization of FF beads
  • 4.4. Fast DNA hybridization using magnetic collection of FF beads
  • 4.5. Rapid sandwich immunoassay introducing magnetic collection of FF beads : fast detection of the heart failure biomarker BNP
  • 4.6. Rapid sandwich immunoassay introducing magnetic collection of FFbeads : fast detection of the prostate cancer biomarker PSA
  • 4.7. Rapid immunostaining introducing magnetic collection of FF beads
  • 4.8. Conclusion
  • 5. Development of surface-modified magnetic nanoparticles for medical applications
  • 5.1. Medical uses of magnetic materials
  • 5.2. Preparation of magnetic nanoparticles
  • 5.3. Virus capsid proteins
  • 5.4. Scientific and medical applications of virus capsid protein
  • 5.5. Technologies that modify the surface of viral capsids
  • 5.6. Technologies used to encapsulate materials within the virus capsid
  • 5.7. Development of functional viral capsid-coated artificial beads, including magnetic nanoparticles
  • 5.8. Medical applications of functional viral capsid-coated artificial beads, including magnetic nanoparticles
  • 5.9. Conclusion
  • 6. Magnetic hyperthermia treatment
  • 6.1. Introduction to magnetic hyperthermia
  • 6.2. Principle of magnetic hyperthermia
  • 6.3. Measurement of specific loss power (SLP)
  • 6.4. Iron oxide based heating mediators
  • 6.5. In vivo studies
  • 6.6. Implant-type heating mediators
  • 6.7. Alternating magnetic field applicator
  • 6.8. Prospects
  • 7. Synthesis, dispersion and application of stable magnetic colloids
  • 7.1. Introduction
  • 7.2. History of magnetic fluid
  • 7.3. Synthesis of magnetic nanoparticles
  • 7.4. Stability of magnetic fluid
  • 7.5. Preparation of magnetic fluid
  • 7.6. Magnetic fluid based applications
  • 7.7. Summary
  • 8. Optical and magnetic detection of magnetic beads for medical diagnostics for point of care testing
  • 8.1. Introduction
  • 8.2. Review of magnetic particle detection methods
  • 8.3. Non-specific interaction of magnetic particles
  • 8.4. Design of micro-coils
  • 8.5. Experimental evaluation
  • 8.6. Quantitative detection of biotin
  • 8.7. Digital image processing
  • 8.8. Conclusion and future work.