http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (xxvii, 810 pages) : color illustrations
Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention * In-depth coverage of nuclear receptors, including steps in isolation of steriod hormones and the discovery of intracellular hormone receptors; Tyrosine protein kinases and adaptive immunity; and intracellular calcium * Extensive conceptual colour artwork to assist with comprehension of key topics * Instrumental margin notes highlight milestones in signalling mechanisms DESCRIPTION: Signal Transduction is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields.
Prologue: Signal Transduction, origins and ancestors -- First messengers -- Receptors -- GTP-binding proteins and signal transduction -- Effector enzymes coupled to GTP binding proteins: adenylyl cyclase and phospholipase C -- The regulation of visual transduction and olfaction -- Intracellular calcium -- Calcium effectors -- Phosphorylation and dephosphorylation: protein kinases A and C -- Nuclear receptors -- Growth Factors: Setting the framework -- Signalling pathways operated by receptor protein tyrosine kinases -- Signal transduction to and from adhesion molecules -- Adhesion molecules in the regulation of cell differentiation: Mainly about Wnt -- Activation of the innate immune system: the Toll-like receptor 4 and Signalling through Ubiquitylation -- Traffic of white blood cells -- Tyrosine protein kinases and adaptive immunity : TCR, BCR, soluble tyrosine kinases and NFAT -- Phosphoinositide 3-kinases, protein kinase B and signalling through the insulin receptor -- Protein Kinase C revisited -- Signalling through receptor serine/threonine kinases -- Protein dephosphorylation and protein phosphorylation -- Notch -- Targeting transduction pathways for research and medical intervention -- Protein domains and signal transduction.
Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E.R. Tatham.
Includes bibliographical references and index.
Amsterdam ; Boston : Elsevier/Academic Press, ©2009
113376:113466 Elsevier Science & Technology