Mouse Models for Drug Discovery : Methods and Protocols /
With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular...
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Published: |
New York, NY :
Springer New York : Imprint: Humana Press,
2016.
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| Edition: | 2nd ed. 2016. |
| Series: | Methods in molecular biology.
1438. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Genetically Defined Strains in Drug Development and Toxicity Testing
- Simple, Efficient CRISPR-Cas9 Mediated Gene Editing in Mice: Strategies and Methods
- Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice
- Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells
- Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens
- Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies
- A Humanized Mouse Model to Study Human Albumin and Albumin Conjugates Pharmacokinetics
- Germ-Free Mice Model for Studying Host-Microbial Interactions
- Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans
- Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery
- Cholesterol Absorption and Metabolism
- Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening
- Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research
- Murine Model for Colitis-Associated Cancer of the Colon
- Mouse Models for Studying Depression-Like States and Antidepressant Drugs
- Experimental Models of Anxiety for Drug Discovery and Brain Research
- Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders
- Better Utilization of Mouse Models of Neurodegenerative Diseases in Preclinical Studies: From the Bench to the Clinic
- Neuromuscular Disease Models and Analysis
- Brightfield Imaging and Optical Coherence Tomography of the Mouse Posterior Eye
- Mouse Models as Tools to Identify Genetic Pathways for Retinal Degeneration, as Exemplified by Leber's Congenital Amaurosis.