Vesicular transport in the secretory and endocytic pathways /
| Main Author: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan & Claypool,
2014.
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| Series: | Colloquium digital library of life sciences.
Colloquium series on building blocks of the cell ; # 8. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- 1. Compartmentalization is a hallmark of eukaryotic cells
- 2. Organelles can be classified based on their origin
- 3. There are multiple entry points into the endomembrane system and a network of connecting trafficking routes
- 3.1 The exocytic pathway
- 3.2 The endocytic pathway
- 3.3 The ER-peroxisome pathway
- 4. There are exceptions and extensions to the classic trafficking itineraries
- 4.1 Unconventional secretion
- 4.2 Vesicular transport from mitochondria to peroxisomes and lysosomes
- 5. A mathematical model can explain how organelle size is established and maintained
- 6. Coats and snares constitute the core machinery for vesicle budding and fusion
- 6.1 Vesicle formation
- 6.2 Vesicle fission
- 6.3 Vesicle fusion
- 7. A mathematical model explains how coats and snares are sufficient to generate organelle identity
- 8. How vesicle formation is linked to cargo incorporation
- 8.1 How to avoid empty vesicles
- 8.2 The nature of coat-cargo interactions
- 8.3 Clathrin coated vesicles, endocytosis and exit from the TGN
- 8.4 COPII vesicles, exit from the ER
- 8.5 COPI vesicles, ER retrieval and intra-Golgi transport
- 8.6 Sorting roles of transmembrane domains
- 8.7 Sugars as luminal sorting determinants
- 9. RabGTPases are the master regulators of vesicular traffic
- 9.1 Rab-mediated regulation of coat-cargo recruitment
- 9.2 Vesicle uncoating and tethering
- 9.3 Rab proteins and the actin and microtubule (MT) cytoskeleton in vesicular traffic
- 9.4 Rab proteins and phosphoinositide lipids
- 9.5 Rab domains and Rab cascades
- 10. The mechanisms and physiological roles of endocytosis
- 11. Models for protein transport in the Golgi apparatus
- 12. Summary
- Acknowledgments
- References
- Author biography.