Vesicular transport in the secretory and endocytic pathways /
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| Format: | eBook |
| Language: | English |
| Published: |
San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan & Claypool,
2014.
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| Series: | Colloquium digital library of life sciences.
Colloquium series on building blocks of the cell ; # 8. |
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| Online Access: | Connect to the full text of this electronic book |
| Abstract: | The concept of vesicular traffic as a means of protein transport in and out of cells and between membrane compartments has been established since the 1960s. Its basic principles are beautifully simple, yet the details of protein transport are complex enough to find novel classes of transport vesicles, and trafficking itineraries still being described to date. In this treatise, the reader will be introduced to mechanisms of vesicle sculpting, cargo selection, vesicle targeting, and vesicle consumption that have emerged as common characteristics of multiple transport steps in the exocytic and endocytic pathways. These fundamentals also reveal the basis for the specificity and selectivity of individual transport steps. We will further discuss how protein transport might lead to the establishment and maintenance of the endomembrane system of eukaryotic cells. The concepts for these mechanisms are based on experimental evidence combined with mathematical modeling that can disclose the minimal requirements for the generation of the distinct membrane compartments. |
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| Item Description: | Part of: Colloquium digital library of life sciences. |
| Physical Description: | 1 online resource (viii, 125 pages) : illustrations. Also available in print. |
| Format: | Mode of access: World Wide Web. System requirements: Adobe Acrobat reader. |
| Bibliography: | Includes bibliographical references (pages 93-123). |
| ISBN: | 9781615046591 |
| ISSN: | 2328-305X ; |
| DOI: | 10.4199/C0011ED1V01Y201407BBC008 |
| Access: | Abstract freely available; full-text restricted to subscribers or individual document purchasers. |