Protein translation /
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan & Claypool,
2014.
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| Series: | Colloquium digital library of life sciences.
Colloquium series on building blocks of the cell ; # 6. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Abstract: | Protein synthesis is a fundamental aspect of gene expression across kingdoms. The regulation of translation is important for many biological processes including cell fate determination, development, and growth and is especially crucial to maintain cellular homeostasis during cellular stress and virus infection. Misregulation of protein translation can contribute to diseases such as diabetes, cancer, and neurodegenerative diseases. In this chapter, we highlight the basic understanding of eukaryotic translation and the major regulations that control biological events. We focus on signaling pathways that regulate overall protein synthesis and also mechanisms that control translation of specific mRNAs such as cis-acting elements within the 5' and 3 untranslated regions (UTR). Understanding these mechanisms provide insights into the fundamental gene regulations that may provide new targets for combating disease and virus infections. |
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| Item Description: | Part of: Colloquium digital library of life sciences. Series from website. |
| Physical Description: | 1 online resource (x, 93 pages) : illustrations. Also available in print. |
| Format: | Mode of access: World Wide Web. System requirements: Adobe Acrobat reader. |
| Bibliography: | Includes bibliographical references (pages 69-91). |
| ISBN: | 9781615046317 |
| ISSN: | 2328-305X ; |
| DOI: | 10.4199/C00106ED1V01Y201406BBC006 |
| Access: | Abstract freely available; full-text restricted to subscribers or individual document purchasers. |