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Necrotizing enterocolitis : insights into the pathogenesis of this challenging disease /

Bibliographic Details
Main Author: Caplan, Michael S. (Author)
Format: eBook
Language:English
Published: San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2014.
Series:Colloquium digital library of life sciences.
Colloquium series on integrated systems physiology ; # 48.
Subjects:
Enterocolitis, Neonatal necrotizing.
Enterocolitis, Necrotizing.
TLR4 (human toll-like receptor 4)
bioactive factors
growth factors
human milk
innate immunity
intestinal injury
microbiome
necrotizing enterocolitis
platelet activating factor
premature infant
probiotics
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • 1. Epidemiology and clinical considerations
  • 2. Intestinal physiology and host defense
  • 3. The role of gut flora and commensal microorganisms in neonatal NEC
  • 3 .1 Mechanism of action
  • 3 .2 Is it time?
  • 4. The role of inflammation in neonatal NEC
  • 4.1 Role of inflammation in NEC
  • 4.2 Role of PAF in neonatal NEC
  • 4.2.1 PAF biochemistry and physiology
  • 4.2.2 PAF in intestinal necrosis
  • 4.2.3 Role of PAF in NEC
  • 4.3 PAF activates signaling cascade and apoptosis
  • 4.4 Bacteria stimulate intestinal inflammation
  • 4.5 Role of TLRs in neonatal NEC
  • 4.6 Summary
  • 5. The role of impaired intestinal circulation and PRBC transfusions in NEC
  • 5.1 The role of packed red blood cell transfusions in NEC
  • 6. The impact of feeding and breast milk on NEC
  • 7. The effects of growth factors on NEC
  • 7.1 Epidermal growth factor
  • 7 .2 Transforming growth factor-[beta](TGF-[beta])
  • 7.3 Heparin-binding epidermal growth factor (HB-EGF)
  • 7.4 Erythropoietin (EPO)
  • 7.5 Other growth factors with potential significance to NEC
  • 8. Summary and unifying hypothesis
  • References
  • Author biography.