Necrotizing enterocolitis : insights into the pathogenesis of this challenging disease /

Bibliographic Details
Main Author:	Caplan, Michael S. (Author)
Format:	eBook
Language:	English
Published:	San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2014.
Series:	Colloquium digital library of life sciences. Colloquium series on integrated systems physiology ; # 48.
Subjects:	Enterocolitis, Neonatal necrotizing. Enterocolitis, Necrotizing. TLR4 (human toll-like receptor 4) bioactive factors growth factors human milk innate immunity intestinal injury microbiome necrotizing enterocolitis platelet activating factor premature infant probiotics Electronic books.
Online Access:	Connect to the full text of this electronic book

Description
Abstract:	Necrotizing enterocolitis is an acute inflammatory necrosis of bowel that primarily afflicts premature infants in the neonatal intensive care unit setting. Although patients who develop this disease have high morbidity and mortality rates, the pathogenesis is poorly understood, and therefore there are no specific preventive or treatment strategies that have been clearly effective. Recent studies have suggested that the pathophysiology of necrotizing enterocolitis includes alterations in the inflammatory response leading to dysregulated pro-inflammatory signaling in premature infants, as well as abnormal intestinal bacterial colonization patterns that can activate these inflammatory pathways, and these factors are discussed in depth in the following chapters. While human milk feedings are currently the standard of care for the prevention of this challenging condition, new approaches will be described based on sound evidence that might have a significant impact for premature infants throughout the world.
Item Description:	Part of: Colloquium digital library of life sciences. Series from website.
Physical Description:	1 online resource (ix, 83 pages) : illustrations. Also available in printing.
Format:	Mode of access: World Wide Web. System requirements: Adobe Acrobat reader.
Bibliography:	Includes bibliographical references (pages 61-82).
ISBN:	9781615045914
ISSN:	2154-5626 ;
DOI:	10.4199/C00099ED1V01Y201311ISP048
Access:	Abstract freely available; full-text restricted to subscribers or individual document purchasers.