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A journey through genetics. Part I /

Bibliographic Details
Main Author: Moitra, Karobi (Author)
Format: eBook
Language:English
Published: San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2014.
Series:Colloquium digital library of life sciences.
Colloquium series on the genetic basis of human disease ; # 5.
Subjects:
Mendel, Gregor, > 1822-1884.
DNA > History.
Geneticists > History.
Genetics > History.
DNA > history.
Genetics > history.
DNA
PCR
biology
double helix
genetic code
genetics
molecular biology
timeline
undergraduate biology and RNA
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • 1. The monk who liked to garden
  • 1.1 The early theories of heredity
  • 1.2 The life of Johann Gregor Mendel
  • 1.3 The monk who liked to garden: experiments by Johann Gregor Mendel
  • 1.3.1 Phenotype versus genotype
  • 1.3.2 The monohybrid cross
  • 1.3.3 Mendel's dihybrid cross
  • 1.3.4 Mendel's postulates (laws) of inheritance
  • 1.3.5 Mendel's postulates explained in the light of modern genetics
  • 1.3.6 The chromosomal theory of inheritance and Mendel's laws (Mendel and meiosis)
  • 2. Is DNA the genetic material?
  • 2.1 Frederick Griffith's experiment (1927)
  • 2.2 The Avery, MacLeod, and McCarty experiment (1944)
  • 2.3 Chargaff's laws
  • 2.4 The Hershey-Chase experiment (1952)
  • 3. The race to the double helix
  • 3.1 Naples, Spring 1951: meeting on the structures of large molecules found in living cells
  • 3.2 Jim Watson meets Francis Crick and discovers the fun of talking to him
  • 3.3 Rosalind's talk at Kings College, London (mid-November 1951)
  • 3.3.1 Construction of DNA models--after months of theorizing!
  • 3.3.2 Rosalind's visit does not go well
  • 3.4 Erwin Chargaff and Chargaff's laws
  • 3.4.1 An ill-fated conversation with Erwin Chargaff
  • 3.5 The structure of B-DNA and Jim's visit with Rosalind
  • 3.5.1 Photo 51 and Rosalind Franklin
  • 3.5.2 The correct model--at last!
  • 3.6 The greatest understatement in molecular biology
  • 3.7 Nucleic acid structure
  • 3.8 Detailed structure of the DNA double helix
  • 3.9 Some physical properties of DNA
  • 4. The central dogma of molecular biology
  • 4.1 Crick's original statement of the central dogma
  • 4.2 Envisioning the central dogma
  • 4.3 Disputes regarding the central dogma
  • 5. DNA replication and repair
  • 5.1 The power of gin and tonic: how Matthew Meselson met Frank Stahl
  • 5.1.1 Semi-conservative replication of DNA
  • 5.1.2 Proof that DNA replicates in a semi-conservative fashion: the Meselson and Stahl experiment (1958)
  • 5.2 The mechanism of DNA replication in Prokaryotes
  • 5.3 The coherent model for DNA replication
  • 5.4 Mechanisms of DNA repair
  • 5.5 Other repair systems
  • 6. Cracking the code of life
  • 6.1 The RNA tie club
  • 6.2 The accomplishments of the RNA tie club
  • 6.3 Cracking the code
  • 6.4 The genetic code
  • 7. The story of protein synthesis
  • 7.1 Protein synthesis in prokaryotes
  • 7.2 Activation of amino acids
  • 7.3 Discovering a mechanism for protein synthesis
  • 8. The very unusual origin of the polymerase chain reaction
  • 8.1 The unusual origin of the polymerase chain reaction: a moonlight drive (retold from ref. [34])
  • 8.2 A story of DNA detectives, a whale of a tale
  • 8.3 The master plan
  • 8.3.1 Scott and Naoko's workflow
  • 8.3.2 Basic principle of PCR
  • 8.3.3 Recipe for a PCR
  • 8.4 The results
  • 8.4.1 The polymerase chain reaction exploits features of the DNA replication process
  • References
  • Author biography.