Cover Image

Malaria /

Bibliographic Details
Main Author: Carvalho Tavares, Juliana (Author)
Format: eBook
Language:English
Published: San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2013.
Series:Colloquium digital library of life sciences.
Colloquium series on integrated systems physiology ; # 45.
Subjects:
Malaria.
Malaria > pathology.
blood brain barrier
cerebral malaria
immune system
malaria
neurologic impairment
pathogenesis
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • 1. Malaria pathogenesis / Fernando Fonseca de Almeida e Val, Wuelton Marcelo Monteiro, and Marcus Vinícius Guimarães de Lacerda
  • 1.1 Parasite biomass
  • 1.2 Inflammatory response
  • 1.3 Infected erythrocytes: deformability/rosetting
  • 1.4 Endothelial alterations
  • 1.5 Cytoadherence/sequestration
  • 1.6 Clinical complications
  • 1.6.1 Anemia
  • 1.6.2 Thrombocytopenia/coagulation disorders
  • 1.6.3 Jaundice
  • 1.6.4 Metabolic complications
  • 1.6.5 Pregnancy-related malaria
  • 1.6.6 Respiratory distress and lung injury
  • 1.6.7 Neurological syndrome and coma
  • 1.6.8 Acute renal failure
  • 1.6.9 Algid malaria/shock
  • 1.6.10 Atypical manifestations
  • 1.7 Comorbidities
  • 2. Possible mechanisms to explain plasmodium immunopathogenesis: the role of parasite and human host genetic diversity / Ricardo Luiz Dantas Machado
  • 2.1 Plasmodium falciparum related pathogenesis
  • 2.2 Plasmodium vivax related pathogenesis
  • 2.3 Cytoadherence and virulence of plasmodium knowlesi malaria
  • 2.4 Concluding remarks
  • 3. Malarial anemia: a multifactorial hematological outcome / Luiza Carvalho Mourão, Thiago Castro Gomes, and Erika M. Braga
  • 3.1 Introduction
  • 3.2 Anemia and parasite biomass are not associated
  • 3.3 Rosette formation and cytoadherence
  • 3.4 The participation of inflammatory cytokines
  • 3.5 The involvement of nitric oxide (NO) in anemia
  • 3.6 Phagocytosis of malaria-infected and non-infected RBCs
  • 3.7 Complement proteins and anemia
  • 3.8 The possible role of autoantibodies
  • 3.9 Concluding remarks
  • 4. Immune response to malaria blood stage / Onesia Cristina Oliveira Lima and Juliana Carvalho Tavares
  • 4.1 Introduction
  • 4.2 Mouse models for malaria research
  • 4.3 Life cycle of the malaria parasite
  • 4.4 Dendritic cells
  • 4.5 CD4 T Cells
  • 4.6 NK (natural killer) cells
  • 4.7 CD4+CD25+Foxp3+ regulatory T Cells
  • 4.8 yo T-cel
  • 4.9 Monocite/macrophages
  • 4.10 B cells
  • 4.11 Concluding remarks
  • 5. Human cerebral malaria and experimental models / Leonardo J. M. Carvalho and Yuri C. Martins
  • 5.1 Introduction
  • 5.2 Cerebral malaria: epidemiology, clinical presentation, diagnosis and management
  • 5.3 Pathogenesis
  • 5.4 Adjunctive therapies
  • 5.5 Animal models of CM
  • 5.6 Conclusion
  • 6. Blood-brain barrier disruption in cerebral malaria / Marcelo Limborço Filho and Juliana Carvalho Tavares
  • 6.1 Introduction
  • 6.1.1 Healthy blood-brain barrier: structure and function
  • 6.2 How is it possible to study BBB permeability?
  • 6.3 Rupture of the BBB in CM
  • 6.4 What mechanisms might underlie BBB dysfunction in cerebral malaria?
  • 6.5 PRBC sequestration and interaction with BBB
  • 6.6 Consequences of PRBC adhesion on endothelial cell (BBB)
  • 6.7 Apoptosis of endothelial cell blood brain barrier
  • 6.8 Inflammatory mediators
  • 6.9 Leukocyte and platelet recruitment
  • 6.10 How can platelets modulate EC-PRBC interaction and subsequent sequelae?
  • 6.11 Consequences of BBB rupture on astrocytes and microglia
  • 6.12 Concluding remarks
  • 7. Persistent cognitive and memory impairment after cerebral malaria: molecular mechanisms and pre-clinical models of adjuvant therapy / Patricia Alves Reis, Tatiana Maron-Gutierrez, Hugo Caire de Castro Faria Neto, and Guy Zimmerman
  • 7.1 Introduction
  • 7.2 Cognitive impairment in cerebral malaria, what do we know so far?
  • 7.3 Neuroinflammation and cognitive impairment in cerebral malaria
  • 7.4 Mechanisms of memory impairment after cerebral malaria
  • 7.5 Therapeutic approaches to tissue damage associated to cerebral malaria
  • 7.6 Concluding remarks
  • Bibliography.