Clinical and molecular aspects of motor neuron disease /
| Main Authors: | , , |
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| Format: | eBook |
| Language: | English |
| Published: |
San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan & Claypool,
2013.
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| Series: | Colloquium digital library of life sciences.
Colloquium series on genomic and molecular medicine ; # 4. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Abstract: | In this e-book, motor neuron disease (MND) shall refer to amyotrophic lateral sclerosis (ALS), the most common neurodegenerative disorder affecting both the upper and lower motor neurons. With the discovery of C9 or F72 expansions in approximately 10% of all MND cases, in certain populations, we stand at the brink of a new era of MND research and hopefully treatment facilitated by the ability to associate a relatively large group of patients with a similar disease mechanism. This review will summarise both current clinical management of MND and our present understanding of the molecular pathogenesis of MND. Study of C9 or F72 -MND has the potential to rapidly advance both of these aspects in the coming years. In the first section, we will discuss the clinical features of MND and describe how patients with this devastating condition present, are investigated, and managed in the 21st century. Although, currently, management is limited by an incomplete understanding of disease pathophysiology, there is much which can be done to assist and support patients with MND. In the following sections, we will discuss molecular mechanisms implicated in MND, highlighting observations which unify different theories. Particular attention will be given to placing proposed mechanisms within the clinical course of MND. Furthermore, novel therapeutic targets will be discussed. |
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| Item Description: | Part of: Colloquium digital library of life sciences. Series from website. |
| Physical Description: | 1 online resource (viii, 52 pages) : illustrations. Also available in printing. |
| Format: | Mode of access: World Wide Web. System requirements: Adobe Acrobat reader. |
| Bibliography: | Includes bibliographical references (pages 35-46). |
| ISBN: | 9781615044290 |
| ISSN: | 2167-7859 ; |
| DOI: | 10.4199/C00093ED1V01Y201309GMM004 |
| Access: | Abstract freely available; full-text restricted to subscribers or individual document purchasers. |