Stroke : pathophysiology and therapy /

Bibliographic Details
Main Authors:	Minnerup, Jens (Author), Albert-Weissenberger, Christiane (Author), Kleinschnitz, Christoph (Author), Schmidt, Antje (Author)
Format:	eBook
Language:	English
Published:	San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2013.
Series:	Colloquium digital library of life sciences. Colloquium series on integrated systems physiology ; # 42.
Subjects:	Cerebrovascular disease. Stroke. brain injury cerebral edema cerebral infarction epidemiology excitotoxicity inflammation ischemic stroke pathophysiology recovery regeneration stroke thrombus formation treatment Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

1. Introduction
1.1 Stroke classifications
1.2 Epidemiology
1.3 Acute therapy
1.4 Prevention
2. Pathophysiology of acute injury
2.1 Excitotoxicity
2.2 Oxidative stress
2.2.1 Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are important generators of ROS
2.2.2 Translational aspects
2.3 Inflammatory cascades
2.3.1 Detrimental effects of immune cell infiltration on ischemic brain injury
2.3.2 Beneficial effects of immune cell infiltration on ischemic brain injury
2.3.3 Translational aspects
2.4 Thrombus formation
2.4.1 Thrombus formation and its interrelationship with inflammation
2.4.2 The coagulation cascade as a novel target in stroke therapy
2.4.3 Inhibition of platelet function as a novel treatment strategy for stroke
2.5 Cerebral edema formation
2.5.1 Impact of aquaporin-4 (AQP4) on brain edema formation in ischemic brain injury
2.5.2 The impact of the KKS on brain edema formation in ischemic brain injury
3. Recovery and regeneration
3.1 Neurological impairment after stroke and spontaneous recovery
3.2 Neurogenesis
3.3 Angiogenesis and vasculogenesis
3.4 Axonal sprouting and dendritic plasticity
4. Future therapeutic strategies
4.1 Neuroprotection
4.1.1 Introduction
4.1.2 Translational failures of candidate neuroprotectants
4.1.3 Ongoing studies on neuroprotective drugs for ischemic stroke
4.1.4 Uric acid
4.1.5 Magnesium
4.1.6 Dapsone
4.1.7 Albumin
4.1.8 Ciclosporine
4.1.9 THR-18
4.1.10 PF-03049423
4.1.11 Combining neuroprotection with thrombolysis
4.1.12 Neuroprotection and hypothermia
4.1.13 Conclusions
4.2 Neurorestorative therapies
4.2.1 Mechanisms of spontaneous recovery as basis for future treatments
4.2.2 Growth factor treatment to enhance recovery after stroke
4.2.3 Counteracting inhibition of axonal sprouting
4.2.4 Cell therapy for stroke
4.3 Approaches to improve translation
References.