Developmental programming of cardiovascular disease /

Bibliographic Details
Main Author:	Alexander, Barbara T.
Format:	eBook
Language:	English
Published:	San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan and Claypool, [2013]
Series:	Colloquium digital library of life sciences. Colloquium series on integrated systems physiology ; # 38.
Subjects:	Birth weight, Low. Cardiovascular system > Diseases > Etiology. Hypertension > Etiology. Cardiovascular Diseases > etiology. Hypertension > etiology. Infant, Low Birth Weight. aging cardiovascular disease developmental programming fetal programming hypertension intrauterine growth restriction low birth weight nephron number preterm birth sex differences Electronic books.
Online Access:	Connect to the full text of this electronic book

Description
Abstract:	Numerous epidemiological studies report that birth weight is inversely associated with blood pressure, suggesting that slow growth during fetal life programs hypertension and increased risk for cardiovascular disease in later life. Different experimental models are used to provide proof of concept for the theory of developmental programming of cardiovascular disease, and studies in these different animal models are providing insight into the etiology of chronic disease programmed by an imbalance in nutrition during early life or exposure to maternal complications during pregnancy. Alterations in the regulatory systems key to the long-term control of blood pressure are implicated in the etiology of hypertension that results from adverse exposures during early development. Epigenetic processes are also implicated in the increased risk for programmed cardiovascular disease and the passage of programmed cardiovascular risk to the next generation. Sex, age, and early postnatal growth impact later programmed risk; programmed risk is also amplified in response to a secondary challenge that includes normal physiological processes such as pregnancy. Thus, this book will highlight how events during early life impact later cardiovascular health in a manner that is sex- and age-dependent and can be transmitted to the next generation.
Item Description:	Electronic resource. Part of: Colloquium digital library of life sciences. Series from website.
Physical Description:	1 online resource (ix, 77 pages) : illustrations Also available in printing.
Format:	Mode of access: World Wide Web. System requirements: Adobe Acrobat reader.
Bibliography:	Includes bibliographical references (pages 53-76).
ISBN:	9781615046034 (electronic bk.)
ISSN:	2154-5626 ;
DOI:	10.4199/C00084ED1V01Y201305ISP038
Access:	Abstract freely available; full-text restricted to subscribers or individual document purchasers.