rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Epithelial polarity
  name:
    name part: Apodaca, Gerard (Gerard L.)
    name part: 1961-
    role:
      role term: creator
  name:
    name part: Gallo, Luciana I.
  type of resource: text
  genre: abstract or summary
  genre: Electronic books.
  origin info:
    place:
      place term: cau
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    reformatting quality: access
    form: remote
    extent: 1 online resource (viii, 115 pages) : illustrations
  abstract: Epithelial cells exhibit an apical-basolateral axis of polarity that is generated during embryogenesis, is maintained throughout adult life in the face of constant cell regeneration, and is perturbed in several epithelial-associated diseases. We examine the structural and functional organization of epithelial tissues, as well as the events critical for generating epithelial asymmetry including vectorial trafficking of proteins and lipids, association of signaling and polarity proteins with subdomains of the plasma membrane, and 3D orientation of epithelial cells in response to cell-cell and cell-matrix interactions. As a paradigm to understand how these three processes are coordinated in time and space, we explore apical lumen formation. We also examine the final steps in epithelial morphogenesis, including brush border morphogenesis and ciliogenesis. Finally, we provide examples of disease processes that result from defects in epithelial polarity including diabetes insipidus, microvillar inclusion disease, hereditary deafness, ciliopathies, and cancer.
  table of contents: 1. Introduction -- 2. Epithelial cell organization and asymmetry -- 2.1 Organization and structure of epithelial cells -- 2.2 Plasma membrane asymmetry -- 2.2.1 Apical membrane domain -- 2.2.2 Lateral membrane domain -- 2.2.3 The basal membrane -- 2.3 Membrane organelle and cytoskeletal asymmetry -- 3. Generation and maintenance of epithelial polarity -- 3.1 Model systems to study epithelial polarity -- 3.2 Vectorial trafficking pathways in polarized epithelial cells -- 3.2.1 Biosynthetic pathways -- 3.2.2 Endocytic pathways -- 3.3 The machinery for vectorial sorting and transport of proteins -- 3.3.1 Sorting of basolateral membrane proteins -- 3.3.2 Sorting of apical membrane proteins -- 3.3.3 Transport mechanisms and membrane fusion -- 3.4 Role of polarity complexes and signaling machinery in epithelial polarization -- 3.5 Function of cell-cell and cell-matrix interactions in epithelial polarization -- 3.6 Biogenesis of luminal and basolateral membrane domains -- 3.6.1 Lumen formation -- 3.6.2 Formation of the basolateral domain -- 3.7 Completion of epithelial morphogenesis -- 3.7.1 Brush border morphogenesis -- 3.7.2 Ciliogenesis and membrane traffic -- 3.8 Generation of cellular asymmetry during development --
  table of contents: 4. Diseases that result from defects in epithelial polarity -- 4.1 Mutations that affect sorting and trafficking of membrane proteins -- 4.2 Mutations in the polarized sorting/trafficking machinery -- 4.3 Defects in junction-associated proteins -- 4.4 Ciliopathies -- 4.5 Cancer and epithelial polarity -- Acknowledgments -- References -- Author biographies.
  target audience: specialized
  note: Gerard Apodaca and Luciana I. Gallo.
  note: Electronic resource.
  note: Part of: Colloquium digital library of life sciences.
  note: Series from website.
  note: Abstract freely available; full-text restricted to subscribers or individual document purchasers.
  note: Google book search
  note: Google scholar
  note: Also available in printing.
  note: Mode of access: World Wide Web.
  note: System requirements: Adobe Acrobat reader.
  note: Includes bibliographical references (pages 77-114).
  subject:
    topic: Epithelial cells
    topic: Electric properties
  subject:
    topic: Cell Polarity
  subject:
    topic: Epithelial Cells
  subject:
    topic: apical lumen formation
  subject:
    topic: apical-basolateral axis
  subject:
    topic: epithelial cell culture
  subject:
    topic: epithelial cells
  subject:
    topic: epithelial morphogenesis
  subject:
    topic: epithelial polarity defects
  subject:
    topic: epithelial structure
  subject:
    topic: epithelial tissues
  subject:
    topic: epithelial-associated diseases
  subject:
    topic: membrane trafficking pathways
  subject:
    topic: polarity
  subject:
    topic: sorting and transport of proteins and membranes
  classification: QP88.4 .A653 2013
  classification: 611.0187
  classification: QS 532.5.E7 A653e 2013
  related item:
    note: Google book search
  related item:
    note: Google scholar
  related item:
    title info:
      title: Colloquium digital library of life sciences
  related item:
    title info:
      title: Colloquium series on building blocks of the cell ; # 2
  identifier: 9781615043996 (electronic bk.)
  identifier: 9781615043989 (pbk.)
  identifier: http://proxy.library.tamu.edu/login
  access condition: Abstract freely available; full-text restricted to subscribers or individual document purchasers.
  record info:
    record content source: CaBNVSL
    record creation date: 130422
    record change date: 20210728125131.0
    record identifier: in00003638884