http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (viii, 115 pages) : illustrations
Epithelial cells exhibit an apical-basolateral axis of polarity that is generated during embryogenesis, is maintained throughout adult life in the face of constant cell regeneration, and is perturbed in several epithelial-associated diseases. We examine the structural and functional organization of epithelial tissues, as well as the events critical for generating epithelial asymmetry including vectorial trafficking of proteins and lipids, association of signaling and polarity proteins with subdomains of the plasma membrane, and 3D orientation of epithelial cells in response to cell-cell and cell-matrix interactions. As a paradigm to understand how these three processes are coordinated in time and space, we explore apical lumen formation. We also examine the final steps in epithelial morphogenesis, including brush border morphogenesis and ciliogenesis. Finally, we provide examples of disease processes that result from defects in epithelial polarity including diabetes insipidus, microvillar inclusion disease, hereditary deafness, ciliopathies, and cancer.
1. Introduction -- 2. Epithelial cell organization and asymmetry -- 2.1 Organization and structure of epithelial cells -- 2.2 Plasma membrane asymmetry -- 2.2.1 Apical membrane domain -- 2.2.2 Lateral membrane domain -- 2.2.3 The basal membrane -- 2.3 Membrane organelle and cytoskeletal asymmetry -- 3. Generation and maintenance of epithelial polarity -- 3.1 Model systems to study epithelial polarity -- 3.2 Vectorial trafficking pathways in polarized epithelial cells -- 3.2.1 Biosynthetic pathways -- 3.2.2 Endocytic pathways -- 3.3 The machinery for vectorial sorting and transport of proteins -- 3.3.1 Sorting of basolateral membrane proteins -- 3.3.2 Sorting of apical membrane proteins -- 3.3.3 Transport mechanisms and membrane fusion -- 3.4 Role of polarity complexes and signaling machinery in epithelial polarization -- 3.5 Function of cell-cell and cell-matrix interactions in epithelial polarization -- 3.6 Biogenesis of luminal and basolateral membrane domains -- 3.6.1 Lumen formation -- 3.6.2 Formation of the basolateral domain -- 3.7 Completion of epithelial morphogenesis -- 3.7.1 Brush border morphogenesis -- 3.7.2 Ciliogenesis and membrane traffic -- 3.8 Generation of cellular asymmetry during development --
4. Diseases that result from defects in epithelial polarity -- 4.1 Mutations that affect sorting and trafficking of membrane proteins -- 4.2 Mutations in the polarized sorting/trafficking machinery -- 4.3 Defects in junction-associated proteins -- 4.4 Ciliopathies -- 4.5 Cancer and epithelial polarity -- Acknowledgments -- References -- Author biographies.
Part of: Colloquium digital library of life sciences.
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Includes bibliographical references (pages 77-114).
sorting and transport of proteins and membranes
Colloquium digital library of life sciences
Colloquium series on building blocks of the cell ; # 2