Epithelial polarity /

Bibliographic Details
Main Author:	Apodaca, Gerard (Gerard L.), 1961-
Other Authors:	Gallo, Luciana I.
Format:	eBook
Language:	English
Published:	San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan and Claypool, [2013]
Series:	Colloquium digital library of life sciences. Colloquium series on building blocks of the cell ; # 2.
Subjects:	Epithelial cells > Electric properties. Cell Polarity. Epithelial Cells. apical lumen formation apical-basolateral axis epithelial cell culture epithelial cells epithelial morphogenesis epithelial polarity defects epithelial structure epithelial tissues epithelial-associated diseases membrane trafficking pathways polarity sorting and transport of proteins and membranes Electronic books.
Online Access:	Connect to the full text of this electronic book

Description
Abstract:	Epithelial cells exhibit an apical-basolateral axis of polarity that is generated during embryogenesis, is maintained throughout adult life in the face of constant cell regeneration, and is perturbed in several epithelial-associated diseases. We examine the structural and functional organization of epithelial tissues, as well as the events critical for generating epithelial asymmetry including vectorial trafficking of proteins and lipids, association of signaling and polarity proteins with subdomains of the plasma membrane, and 3D orientation of epithelial cells in response to cell-cell and cell-matrix interactions. As a paradigm to understand how these three processes are coordinated in time and space, we explore apical lumen formation. We also examine the final steps in epithelial morphogenesis, including brush border morphogenesis and ciliogenesis. Finally, we provide examples of disease processes that result from defects in epithelial polarity including diabetes insipidus, microvillar inclusion disease, hereditary deafness, ciliopathies, and cancer.
Item Description:	Electronic resource. Part of: Colloquium digital library of life sciences. Series from website.
Physical Description:	1 online resource (viii, 115 pages) : illustrations Also available in printing.
Format:	Mode of access: World Wide Web. System requirements: Adobe Acrobat reader.
Bibliography:	Includes bibliographical references (pages 77-114).
ISBN:	9781615043996 (electronic bk.)
DOI:	10.4199/C00077ED1V01Y201303BBC002
Access:	Abstract freely available; full-text restricted to subscribers or individual document purchasers.