Genetics of epilepsy and refractory epilepsy /
| Main Author: | |
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| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan and Claypool,
[2013]
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| Series: | Colloquium digital library of life sciences.
Colloquium series on the genetic basis of human disease ; # 2. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Introduction
- What is epilepsy?
- Resting potential
- Action potential
- Are there any genetic bases for epilepsy?
- Ligand-gated ion channels
- Acetylcholine receptors CHRNA4, CHRNB2, and CHRNA2
- Ion channels
- Sodium channels
- Potassium channel subunit mutations with LOF effects
- Voltage-gated calcium channel mutations and genetic susceptibility
- GABA receptor subunit mutations (chloride channel)
- Copy number variants and comorbidities
- Susceptibility genes for complex epilepsy
- Glycine receptors
- Ionotropic glutamate receptors
- G-protein-coupled receptors
- Metabotropic glutamate receptors
- Other genetic causes of epilepsy
- Mitochondrial inheritance and myoclonic epilepsy with ragged red fibers
- Leucine-rich glioma inactivated gene 1 (LGI1)
- Inborn errors of metabolism and epilepsy
- Epilepsy and NMDs
- FOLR1 gene mutation
- Lysosomal storage disorders
- The solute-carrier gene superfamily and epilepsy
- Genes related with different epileptic syndromes
- Genetic mechanisms of drug resistance in epilepsy
- Definition of drug resistance in epilepsy
- Genetics of drug response in epilepsy
- Drug transport system
- ABC transporters
- ABC transporters and RE
- MDR1 (ABCB1) gene variants
- The BBB's role in pharmacoresistance in epilepsy
- Induction of ABC transporters: is the acquired refractoriness an inducible process?
- Genes and pharmacodynamic modifications
- Inducing the expression of P-gp in neurons: is it to induce epileptogenesis?
- References
- Author biographies.