Stem cells and progenitors in liver development /
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan and Claypool,
[2013]
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| Series: | Colloquium digital library of life sciences.
Colloquium series on stem cell biology ; # 3. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Abstract: | The human liver is a dynamic organ throughout life, but no more so than during prenatal development. The liver performs many essential functions associated with metabolism, immunity and blood production. These diverse functions are performed by a variety of cell types that have the capacity for growth, allowing the liver to regenerate cells lost due to aging, infection or injury. Various stem cell populations are at the core of the liver's potential for regeneration, which are most active during embryonic and fetal development, when the liver undergoes rapid growth. Consequently, the prenatal liver represents a unique opportunity to study the precursor cells that give rise to all liver cells at their time of greatest activity. Herein, we focus on the early development of the human liver from the perspective of the stem cells and their many lines of progeny that generate the hepatic, endothelial, mesenchymal and hematopoietic cells that comprise the fetal liver. Understanding the developmental relationships, growth control and cellular interactions among these cells is crucial to our understanding of liver development and function during prenatal life. This knowledge also provides insight into the development of cellular therapies, transplantation and the treatment of cancers. |
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| Item Description: | Electronic resource. Part of: Colloquium digital library of life sciences. Series from website. |
| Physical Description: | 1 online resource (ix, 115 pages) : illustrations Also available in printing. |
| Format: | Mode of access: World Wide Web. System requirements: Adobe Acrobat reader. |
| Bibliography: | Includes bibliographical references (pages 89-114). |
| ISBN: | 9781615044894 (electronic bk.) |
| ISSN: | 2168-3980 ; |
| DOI: | 10.4199/C00070ED1V01Y201212SCB003 |
| Access: | Abstract freely available; full-text restricted to subscribers or individual document purchasers. |