Airway epithelium /

Bibliographic Details
Main Author:	Widdicombe, J. H.
Format:	eBook
Language:	English
Published:	San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan and Claypool, [2013]
Series:	Colloquium digital library of life sciences. Colloquium series on integrated systems physiology ; # 36.
Subjects:	Airway (Medicine) Epithelium. Respiratory mucosa. Respiratory organs > Diseases. Respiratory Mucosa. Respiratory Tract Diseases. active ion transport airway epithelium antimicrobials asthma cystic fibrosis mucociliary clearance mucus secretion submucosal glands transepithelial fluid movement Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

1. Overview
2. Surface epithelium
2.1 Overall morphology
2.2 Cell types
2.2.1 Basal and intermediate cells
2.2.2 Ciliated cells
2.2.3 Goblet cells
2.2.4 Clara cells
2.2.5 Serous cells
2.2.6 Other cell types
2.3 Development, maintenance, regeneration and transformation
2.4 Barrier function
2.5 Mucus secretion
2.6 Mediator release and breakdown
2.7 Transport of acid and base
2.8 Active ion transport
2.8.1 General
2.8.2 Using chambers
2.8.3 Mechanisms of active Cl- secretion and active Na+ absorption
2.8.4 Under open-circuit conditions active secretion of Cl- is reduced or abolished
2.8.5 Coordination of transporter activities
2.8.6 Apical membrane Cl- conductance
2.8.7 Epithelial Na+ channel (ENaC)
2.8.8 Basolateral K+ channels
2.8.9 Na+-K+-2Cl- cotransport (NKCC)
2.8.10 Na+-K+-ATPase
2.8.11 Basolateral Cl- channels
2.8.12 Neurohumoral regulation
2.8.13 Regulation by intracellular second messengers
2.8.14 K+ secretion
2.8.15 SCN- transport
2.8.16 Ca2+ transport
2.8.17 Na+-glucose transport
2.9 Water transport
2.10 Regulation of ASL depth and salt content
2.11 Mucociliary clearance
3. Airway glands
4. Pathology
4.1 Some general considerations
4.2 Chronic bronchitis
4.3 Asthma
4.4 Cystic fibrosis
4.4.1 Gross pathology
4.4.2 Overview of CF-related defects
4.4.3 Reduced bicarbonate secretion
4.4.4 Altered gland fluid secretion
4.4.5 Airway surface epithelial ion transport and failure of mucociliary clearance in CF
4.4.6 The high salt hypothesis
4.4.7 Transport of other solutes through CFTR
4.4.8 Defective organellar acidification
4.4.9 Interactions of CFTR with ion channels/transporters other than ENaC
4.4.10 Increased activation of NFk-B and release of inflammatory cytokines
4.4.11 Altered interactions with pseudomonas
4.4.12 Some developmental defects
4.4.13 Other changes in CF
4.4.14 Concluding remarks on airway epithelium in CF
References
Author biography.