Table of Contents:
  • 1. Introduction
  • 2. Genetics of stroke
  • 3. Single-gene disorders associated with stroke
  • 4. Genetics of common forms of stroke
  • 4.1 Strategies for genetic analysis of stroke
  • 4.2 Molecular pathophysiology of ischemic stroke
  • 4.3 Molecular genetics of ischemic stroke
  • 4.3.1 Phosphodiesterase 4D, cAMP-specific gene (PDE4D)
  • 4.3.2 Arachidonate 5-lipoxygenase-activating protein gene (ALOX5AP)
  • 4.3.3 CDKN2B antisense RNA 1 gene (CDKN2B-AS1)
  • 4.3.4 Ninjurin 2 gene (NINJ2)
  • 4.3.5 Paired-like homeodomain 2 gene (PITX2) and zinc finger homeobox 3 gene (ZFHX3)
  • 4.4 Molecular pathophysiology of intracerebral hemorrhage
  • 4.5 Molecular genetics of intracerebral hemorrhage
  • 4.5.1 Apolipoprotein E gene (APOE )
  • 4.5.2 Collagen, type IV, alpha 1 gene (COL4A1)
  • 4.6 Molecular pathophysiology of intracranial aneurysm and subarachnoid hemorrhage
  • 4.7 Molecular genetics of intracranial aneurysm and subarachnoid hemorrhage
  • 4.7.1 Elastin gene (ELN) and LIM domain kinase 1 gene (LIMK1)
  • 4.7.2 Tumor necrosis factor receptor superfamily, member 13b gene (TNFRSF13B)
  • 4.7.3 Five loci for intracranial aneurysm identified by GWASs
  • 5. Clinical implications
  • 6. Conclusion
  • References
  • Titles of related interest.