Intestinal water and electrolyte transport in health and disease /
| Main Author: | |
|---|---|
| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Published: |
San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan and Claypool,
[2012]
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| Series: | Colloquium digital library of life sciences.
Colloquium series on integrated systems physiology ; # 31. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- 1. Overview
- 2. Epithelial cell and tissue architecture
- 2.1 Polarized epithelial cell
- 2.2 Tight junctions
- 3. Principles of transepithelial electrolyte and water movement
- 3.1 Transcellular movement
- 3.2 Paracellular movement
- 4. Intestinal architecture and electrolyte transport
- 4.1 Segmental heterogeneity of transport down the crypt-villus and crypt-surface axes
- 4.2 Segmental heterogeneity of transport down the cephalocaudal axis
- 5. Electrolyte transporters, pumps, carriers, and channels
- 5.1 Transport of cations
- 5.1.1 Sodium
- 5.1.1.1 Sodium-potassium ATPase
- 5.1.1.2 Sodium-coupled glucose transport
- 5.1.1.3 Sodium-hydrogen exchanger
- 5.1.1.4 Sodium channel
- 5.1.2 Potassium
- 5.1.2.1 Potassium absorption
- 5.1.2.2 Potassium channels and secretion
- 5.2 Transport of anions
- 5.2.1 Chloride
- 5.2.1.1 Chloride absorption
- 5.2.1.2 Chloride secretion
- 5.2.1.2.1 Na+-K+-2Cl- cotransport
- 5.2.1.2.2 CFTR chloride channeL
- 5.2.1.2.3 ClC chloride channels
- 5.2.1.2.4 Ca2+-activated chloride channels
- 5.2.2 Bicarbonate
- 5.2.3 Short-chain fatty acid
- 6. Water transport
- 6.1 Routes of water transport
- 6.2 Aquaporins
- 6.2.1 Aquaporin structure and function
- 6.2.2 Relevance of aquaporins in the intestine
- 6.3 Uniporters and cotransporters
- 6.4 Mechanisms of water transport in the intestine
- 7. Regulation
- 7.1 Intracellular mediators
- 7.1.1 Cyclic AMP
- 7.1.2 Cyclic GMP
- 7.1.3 Calcium
- 7.1.4 Protein kinases
- 7.1.5 Compartmentalization
- 7.1.6 Transcriptional and translational control
- 7.2 PINES: Paracrine-Immuno-Neuro-Endocrine System
- 7.2.1 Autocrine, paracrine, and juxtacrine regulation
- 7.2.2 Immunologic regulation
- 7.2.3 Neural regulation
- 7.2.4 Endocrine regulation
- 7.2.4.1 Absorptive factors
- 7.2.4.2 Steroid hormones
- 7.2.4.3 Secretory factors
- 7.2.4.4 Guanylin and nitric oxide
- 7.3 Other regulatory effects
- 7.3.1 Developmental regulation
- 7.3.2 Systemic effects
- 7.3.3 Osmotic effects
- 7.3.4 Homocellular regulation
- 8. Intestinal disorders and advances toward better treatment of intestinal disorders
- 8.1 Infections
- 8.2 Bile acid- and fatty acid-induced diarrheas
- 8.3 Inflammation
- 8.4 Genetic diseases (cystic fibrosis and congenital chloridorrhea)
- 8.5 Constipation
- 8.6 Oral rehydration therapy
- 9. Conclusion
- References.