Intestinal water and electrolyte transport in health and disease /

Bibliographic Details
Main Author:	Rao, Mrinalini C.
Other Authors:	Ao, Mei, Sarathy, Jayashree
Format:	eBook
Language:	English
Published:	San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan and Claypool, [2012]
Series:	Colloquium digital library of life sciences. Colloquium series on integrated systems physiology ; # 31.
Subjects:	Biological transport. Body fluid flow. Intestines > Secretions. Biological Transport. Body Fluids. Intestinal Secretions. anion and cation transport electrolyte and water movement epithelial cell intestinal architecture intestinal disorders pumps and channels regulation of intestinal transport transepithelial transport transporters Electronic books.
Online Access:	Connect to the full text of this electronic book

Description
Abstract:	The unique architecture and physiology of the mammalian intestine, together with a tightly coordinated regulatory system, allows for the handling and absorption of as much as 9 L of fluid a day with 98% or greater efficiency. Advances in the past 40 years have made inroads into revealing the intricacies and interplay of numerous ion transporters and their modulators that are responsible for intestinal electrolyte and water transport. Studies of two devastating diseases, the virulent infectious disease cholera and the autosomal recessive disease cystic fibrosis, were largely responsible for this information explosion. These advances have been critical in the development of new therapeutic strategies to combat life-threatening diseases of varying etiologies ranging from enteric infections to cystic fibrosis and inflammatory bowel diseases. Yet, the story is far from complete, and progress needs to continue on translating information gained from reductionistic cell and tissue culture models, in vivo models, and ultimately human studies and on improving therapeutic approaches. This book reviews the current status of our knowledge of fluid transport across the intestine, including the complexities of transcellular and paracellular ion transport down the length of the intestine and how aberrations of normal physiological processes lead to disease.
Item Description:	Electronic resource. Part of: Colloquium digital library of life sciences. Series from website.
Physical Description:	1 online resource (ix, 105 pages) : illustrations Also available in printing.
Format:	Mode of access: World Wide Web. System requirements: Adobe Acrobat reader.
Bibliography:	Includes bibliographical references (pages 95-105).
ISBN:	9781615041572 (electronic bk.)
ISSN:	2154-5626 ;
DOI:	10.4199/C00049ED1V01Y201112ISP031
Access:	Abstract freely available; full-text restricted to subscribers or individual document purchasers.