rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: immune system and the developing brain
  name:
    name part: Schwarz, Jaclyn M.
    role:
      role term: creator
  name:
    name part: Bilbo, Staci D.
  type of resource: text
  genre: abstract or summary
  genre: Electronic books.
  origin info:
    place:
      place term: cau
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    reformatting quality: access
    form: remote
    extent: 1 online resource (ix, 118 pages) : illustrations
  abstract: The developing brain is exquisitely sensitive to both endogenous and exogenous signals which direct or significantly alter the developmental trajectory of cells, neural circuits, and associated behavioral outcomes for the life of the individual. Contrary to initial dogma that the brain is one of the few organs within the body that is immune-privileged, evidence indicates that the immune system has a critical role in brain function during development as well as during sickness and health in adulthood. Microglia are the primary immune cells within the brain, and they are in constant communication with the peripheral immune system and surrounding cell types within the brain. We describe the important role of the immune system, including microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition. Growing evidence indicates that there is a strong link between many neuropsychiatric disorders and immune dysfunction, with a distinct etiology in neurodevelopment. Thus, understanding the role of the immune system and immune activation during the critical period of brain development is a necessary step toward understanding the potential origins of these devastating disorders.
  table of contents: 1. Introduction -- 2. The immune response -- 2.1 Sickness behavior: evidence of a brain-immune link -- 3. Brain-immune communication -- 3.1 The autonomic nervous system -- 3.2 The hypothalamic-pituitary-adrenal axis -- 3.3 Cytokines and the brain -- 3.4 Cytokines and the blood-brain barrier -- 3.5 Infiltration of mononuclear cells from the periphery -- 4. Microglia are immune cells of the brain -- 4.1 The origin of microglia in the developing rodent brain -- 4.2 Colonization of microglia within the human brain -- 4.3 Microglia have a distinct morphology during early brain development -- 5. The functional role of microglia and immune molecules in neurodevelopment -- 5.1 Cytokines and immune molecules in neurodevelopment -- 5.2 Sex differences in glial colonization and morphology --
  table of contents: 10. Toll-like receptors and immune activation during early brain development -- 10.1 PAMPs, DAMPs, and the toll-like receptors -- 10.2 The role of alarmins in brain development and the risk of neural and cognitive dysfunction -- 10.3 Alarmins and childhood epileptic disorders -- 10.4 Alarmins and perinatal traumatic brain damage -- 11. Environmental triggers of TLR activation: long-term programming of brain and behavior -- 11.1 Long-term effects of a maternal high-fat diet on brain and behavior: programming the neuroimmune system via TLR4 -- 11.2 Activation of TLR4 by drugs of abuse: effects on the developing brain and later-life behaviors -- 12. Future directions to understanding immune function and brain development -- 12.1 Which comes first: immune dysfunction or neural dysfunction? -- 12.2 Is there a critical threshold of immune activation required for long-term programming? -- References -- Author biographies.
  table of contents: 6. Early-life programming of brain and behavior: a critical role for the immune system -- 6.1 Sickness behavior: a well-known example of immune function affecting neural function -- 6.2 Neuropsychiatric disorders and immune function: an extension of sickness behavior? -- 6.3 Developmental origins of neuropsychiatric disorders -- 7. Commonly used models of early life immune activation in the rodent -- 7.1 Lipopolysaccharide: a model of early life immune activation -- 7.2 E. coli infection: a model of early life bacterial infection -- 7.3 Poly IC: a model of early life viral infection -- 7.4 Is there a sensitive period for long-term consequences of early life immune activation? -- 8. Early life immune activation and cognitive impairment in adulthood -- 8.1 Long-term consequences of early life infection: disruption of neurotransmission and synaptic processes necessary for learning and memory -- 8.2 Long-term consequences of early life infection: alterations in immune function and associated cognitive dysfunction -- 8.3 Long-term alterations in immune function and associated cognitive dysfunction: a role for cytokines? -- 8.4 The very long-term consequences of early life infection: increased vulnerability for aging-related glial activation and associated cognitive decline -- 9. Mechanisms underlying the enduring changes in neuroimmune function caused by early life infection -- 9.1 Long-term changes in microglial function -- 9.2 Potential mechanisms of glial priming -- 9.2.1 Innate immune memory -- 9.2.2 Glial-neuronal interactions -- 9.2.3 Glial-T cell interactions -- 9.2.4 Epigenetic alterations --
  target audience: specialized
  note: Jaclyn M. Schwarz, Staci D. Bilbo.
  note: Electronic resource.
  note: Part of: Colloquium digital library of life sciences.
  note: Series from website.
  note: Abstract freely available; full-text restricted to subscribers or individual document purchasers.
  note: Google book search
  note: Google scholar
  note: Also available in printing.
  note: Mode of access: World Wide Web.
  note: System requirements: Adobe Acrobat reader.
  note: Includes bibliographical references (pages 85-115).
  subject:
    topic: Developmental neurobiology
  subject:
    topic: Microglia
  subject:
    topic: Neuroimmunology
  subject:
    topic: Brain
    topic: growth & development
  subject:
    topic: Brain
    topic: immunology
  subject:
    topic: Microglia
  subject:
    topic: Toll-Like Receptors
  subject:
    topic: chemokines
  subject:
    topic: cognition
  subject:
    topic: cytokines
  subject:
    topic: hippocampus
  subject:
    topic: infection
  subject:
    topic: microglia
  subject:
    topic: sensitive periods
  classification: QP356.47 .S355 2012
  classification: 616.079
  classification: QW 568 S355i 2012
  related item:
    note: Google book search
  related item:
    note: Google scholar
  related item:
    title info:
      title: Colloquium digital library of life sciences
  related item:
    title info:
      title: Colloquium series on the developing brain. # 4
  identifier: 9781615043521 (electronic bk.)
  identifier: 9781615043514 (pbk.)
  identifier: http://proxy.library.tamu.edu/login
  access condition: Abstract freely available; full-text restricted to subscribers or individual document purchasers.
  record info:
    record content source: CaBNVSL
    record creation date: 111116
    record change date: 20210728125127.0
    record identifier: in00003611408