Heme oxygenase and the kidney /
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan and Claypool,
[2011]
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| Series: | Colloquium digital library of life sciences.
Colloquium series on integrated systems physiology, from molecule to function. # 24. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Abstract: | Heme oxygenases (HOs) are the enzymes responsible for the breakdown of heme and the generation of biliverdin/bilirubin and carbon monoxide (CO). The kidney is a complex organ consisting of many different cell types all working together for the single purpose of filtering the blood to eliminate waste products and conserving ions, minerals, and water necessary for life. HO enzymes and their products play a critical role in the normal function of the kidney as well as protecting the kidney from various insults including ischemia and exposure to nephrotoxins. For example, the HO metabolite, bilirubin, is a potent antioxidant which can limit damage to renal tubular epithelial cells following exposure to nephrotoxins associated with chemotherapy or traumatic injury. Another HO metabolite, CO, is an important vasodilator of renal blood vessels and helps protect against severe decreases in renal blood flow in conditions as diverse as exposure to radiocontrast agents and in hypertension-induced kidney disease. HO and its metabolites also play an important role in the survival of kidney cells after acute and chronic injuries by regulating important cell growth and programmed cell death pathways. The intent of this volume is to highlight the important role that HO enzymes and their related metabolites, bilirubin and CO, play in the regulation of renal function and in the response of the kidney to both acute and chronic pathologies. |
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| Item Description: | Electronic resource. Part of: Colloquium digital library of life sciences. Series from website. |
| Physical Description: | 1 online resource (viii, 71 pages) : illustrations Also available in printing. |
| Format: | Mode of access: World Wide Web. System requirements: Adobe Acrobat reader. |
| Bibliography: | Includes bibliographical references (pages 51-69). |
| ISBN: | 9781615042142 (electronic bk.) |
| ISSN: | 2154-5626 ; |
| DOI: | 10.4199/C00036ED1V01Y201107ISP024 |
| Access: | Abstract freely available; full-text restricted to subscribers or individual document purchasers. |