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The endothelium. Part II, EDHF-mediated responses "The classical pathway" /

Bibliographic Details
Main Author: Félétou, Michel, 1956-
Format: eBook
Language:English
Published: San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan and Claypool, [2011]
Series:Colloquium digital library of life sciences.
Colloquium series on integrated systems physiology, from molecule to function. # 20.
Subjects:
Endothelins.
Endothelium.
TRP channels
atherosclerosis
calcium channels
diabetes
hypertension
membrane potential
myo-endothelial gap junctions
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • 1. Endothelium-dependent hyperpolarizations: the classical "EDHF" pathway
  • 1.1 The classical "EDHF" pathway: historical notes
  • 1.2 Early characterization of EDHF-mediated responses
  • 1.3 Identification and localization of the potassium channels involved in EDHF-mediated responses
  • 1.4 Fundamental role of endothelial cell hyperpolarization
  • 1.5 Beyond endothelial cell hyperpolarization
  • 1.5.1 Myoendothelial gap junctions
  • 1.5.2 Regulation of gap junction communication
  • 1.5.3 Potassium ion accumulation in the intercellular space
  • 1.5.3.1 Physiological evidence
  • 1.5.3.2 Potassium cloud theory
  • 1.6 Why two populations of endothelial potassium channels: SKca and IKca
  • 1.6.1 SKca localization and postulated function
  • 1.6.2 IKca localization and postulated function
  • 1.6.3 Regulation of IKca and SKca activity
  • 1.7 Lessons from genetically modified animals
  • 1.7.1 NOS and COX genes
  • 1.7.2 TRP channel genes
  • 1.7.3 Potassium channel genes
  • 1.7.4 Connexin genes
  • 1.8 Physiological role of EDHF-mediated responses
  • 1.8.1 EDHF-mediated responses and arterial blood pressure
  • 1.8.2 Flow-mediated vasodilatation
  • 1.8.3 Conducted vasodilatation
  • 1.8.4 Vasomotion
  • 1.8.5 Hypoxia
  • 1.8.6 EDHF-mediated responses and gender
  • 1.8.6.1 Sex hormones
  • 1.8.6.2 Pregnancy
  • 1.9 Cardiovascular diseases and alterations in EDHF-mediated responses
  • 1.9.1 Impairment of EDHF-mediated responses
  • 1.9.1.1 Hypertension
  • 1.9.1.1.1 Genetic models of hypertension
  • 1.9.1.1.2 Induced hypertension
  • 1.9.1.1.3 Human hypertension and eclampsia
  • 1.9.1.2 Aging
  • 1.9.1.3 Diabetes
  • 1.9.1.3.1 Insulin-dependent diabetes
  • 1.9.1.3.2 Insulin-independent diabetes
  • 1.9.1.4 Angioplasty
  • 1.9.1.5 Transplantation
  • 1.9.1.6 Sepsis
  • 1.9.2 Enhancement of EDHF-mediated responses
  • 1.9.2.1 Hypercholesterolemia and atherosclerosis
  • 1.9.2.2 Diabetes
  • 1.9.2.3 Ischemia-reperfusion
  • 1.9.2.4 Heart failure
  • 1.9.2.5 Hypertension
  • 1.9.2.5.1 Renal circulation
  • 1.9.2.5.2 NOS inhibition or deletion
  • 1.9.2.5.3 Miscellaneous
  • 1.10 Potential therapeutic interventions
  • Conclusion
  • References
  • Author biography.