Regulation of cardiac contractility /
| Main Author: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan and Claypool,
[2011]
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| Series: | Colloquium digital library of life sciences.
Colloquium series on integrated systems physiology, from molecule to function. # 18. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Introduction: contractility and the integrative biology of the myocardium
- Contractility in the modern context
- Control of cardiac contractility is critical to the matching of cardiac output to venous return during exercise with little change in end diastolic volume and with tuning of the dynamics of contraction and relaxation to heart rate
- Control of contractility is at the cellular level of organization
- Left ventricular diastolic and systolic pressure, ejection, and relaxation reflect sarcomeric mechanical properties
- Integration of sarcomere mechanics with cardiac function clarifies the meaning of preload, afterload, and contractility
- Pressure volume loops provide a quantification of contractility
- Phosphorylations of regulatory proteins in excitation contraction coupling modify contractility by controlling cellular Ca2+ fluxes, the response of the myofilaments to Ca2+, and the kinetics of the cross-bridge cycle
- Contractility may be altered by a variety of mechanisms not involving a prominent role for the autonomic nervous system
- Cardiac function curves provide a compact graphical representation of regulation of CO and SV
- Heart failure as a failure of contractility
- References
- Author biography.