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Inflammation and the microcirculation /

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Bibliographic Details
Main Author: Granger, D. Neil
Other Authors: Senchenkova, Elena
Format: eBook
Language:English
Published: San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan and Claypool, [2010]
Series:Colloquium digital library of life sciences.
Colloquium series on integrated systems physiology, from molecule to function. # 8.
Subjects:
Inflammation.
Microcirculation disorders.
Microcirculation.
Angiogenesis
Leukocyte adhesion
Thrombosis
Vascular permeability
Vasomotor function
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • 1. Introduction
  • 2. Historical perspectives
  • 3. Anatomical considerations
  • Microvascular unit
  • Arterioles
  • Capillaries
  • Venules
  • Vessel wall components
  • Endothelial cells
  • Vascular smooth muscle
  • Pericytes
  • Perivascular auxiliary cells
  • Mast cells
  • Macrophages
  • Fibroblasts
  • 4. Impaired vasomotor responses
  • Blood flow changes
  • Endothelium-dependent vasodilation
  • 5. Capillary perfusion
  • 6. Angiogenesis
  • Relevance to inflammation
  • Mediators of the angiogenic response
  • Vascular endothelial cell growth factor
  • Cytokines and chemokines
  • Reactive oxygen and nitrogen species
  • Lymphangiogenesis
  • 7. Leukocyte-endothelial cell adhesion
  • Adhesion molecules
  • Intraorgan heterogeneity of adhesion
  • Selectins
  • Endothelial cells immunoglobulin-like adhesion molecules
  • Leukocyte integrins
  • Chemical mediators
  • Pro-adhesive mediators
  • Anti-adhesive mediators
  • Role of hydrodynamic forces
  • Cytotoxicity of adherent leukocytes
  • 8. Platelet-vessel wall interactions
  • Platelet activation: mechanisms and consequences
  • Platelet-endothelial adhesion
  • Platelet-leukocyte adhesion
  • Platelet-leukocyte aggregates
  • 9. Coagulation and thrombosis
  • Interdependence of coagulation and inflammation
  • Inflammation-induced microvascular thrombosis: site-specific responses
  • Chemical mediators of inflammation-enhanced thrombosis
  • Reactive oxygen and nitrogen species
  • 10. Endothelial barrier dysfunction
  • Site of inflammation-induced barrier failure
  • Role of circulating blood cells
  • Leukocytes
  • Platelets
  • Role of perivascular cells
  • Reactive oxygen and nitrogen species
  • Epilogue
  • References.