FGF signalling in vertebrate development /
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan and Claypool,
[2010]
|
| Series: | Colloquium digital library of life sciences.
Colloquium series on developmental biology ; # 2. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Abstract: | The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right-left asymmetry. |
|---|---|
| Item Description: | Electronic resource. Part of: Colloquium digital library of life sciences. Series from website. Title from PDF title page (viewed on June 10, 2010). |
| Physical Description: | 1 online resource (viii, 75 pages) : illustrations Also available in printing. |
| Format: | Mode of access: World Wide Web. System requirements: Adobe Acrobat reader. |
| Bibliography: | Includes bibliographical references (pages 55-74a). |
| ISBN: | 9781615040643 (electronic bk.) |
| DOI: | 10.4199/C00011ED1V01Y201004DEB002 |
| Access: | Abstract freely available; full-text restricted to subscribers or individual document purchasers. |